The Protective Effect of Losartan on Diabetic Neuropathy in a Diabetic Rat Model

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dc.contributor.authorCavusoglu T.
dc.contributor.authorKaradeniz T.
dc.contributor.authorCagiltay E.
dc.contributor.authorKaradeniz M.
dc.contributor.authorYigitturk G.
dc.contributor.authorAcikgoz E.
dc.contributor.authorUyanikgil Y.
dc.contributor.authorAtes U.
dc.contributor.authorTuglu M.I.
dc.contributor.authorErbas O.
dc.date.accessioned2019-10-26T21:22:40Z
dc.date.available2019-10-26T21:22:40Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Involvement of the peripheral and autonomic nervous systems is possibly the most frequent complication of diabetes. Important risk factors included hyperglycemia, dyslipidemia, hypertension, and smoking. Angiotensin-converting-enzyme inhibitor (ACE) inhibitors should be beneficial in all vascular beds, including neuropathy and retinopathy. In this study we aimed to evaluate the effect of the angiotensin receptor blocker losartan on diabetic neuropathy in a diabetic rat model. Material and Methods: 24 male, Sprague Dawley albino mature rats were divided into 3 groups; (1) control group: No drug was administered to the remainder of rats which blood glucose levels were under 120mg/dl, (2) diabetic control: rats were given no medication, but 4ml per day of tap water was given by oral gavage, (3) losartan groups: rats were given 10mg/kg/day oral of losartan for 4 weeks. Electromyography (EMG) was applied to anesthetized rats at the end of 4th weekend. Then, the animals were euthanized and sciatic nerve was performed for histopathological examination. Results: Compound Muscle Action Potential (CMAP) amplitude of diabetic rats receiving the Saline in the EMG was significantly reduced when compared to the control group. Distal latency value and CMAP duration of diabetic rats receiving the saline were meaningfully increased when compared to the control group. CMAP amplitude and CMAP duration of diabetic rats receiving the Losartan treatment in the EMG were meaningfully reduced when compared to diabetic rats receiving the Saline. Perineural thickness in the rats receiving the Losartan treatment was found to be significantly reduced when compared to the group receiving the Saline. Conclusions: As a result, it has been shown in this study that perineural thickness of the Losartan treatment was significantly reduced when compared to saline receiving group, significantly increased the immunoexpression of NGF, and also provided a significantly recovery in EMG when compared to Saline receiving group. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart, New York.en_US
dc.identifier.doi10.1055/s-0035-1550019en_US
dc.identifier.endpage484en_US
dc.identifier.issn0947-7349
dc.identifier.issue8en_US
dc.identifier.pmid26011170en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage479en_US
dc.identifier.urihttps://doi.org/10.1055/s-0035-1550019
dc.identifier.urihttps://hdl.handle.net/11454/16988
dc.identifier.volume123en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlagen_US
dc.relation.ispartofExperimental and Clinical Endocrinology and Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiabetesen_US
dc.subjectelectromyographyen_US
dc.subjecthistopathologicalen_US
dc.subjectlosartanen_US
dc.subjectmedicineen_US
dc.titleThe Protective Effect of Losartan on Diabetic Neuropathy in a Diabetic Rat Modelen_US
dc.typeArticleen_US

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