Evaluation of post-COVID symptoms of the SARS-CoV-2 Delta and Omicron variants in children: a prospective study

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dc.authorscopusid57222317768
dc.authorscopusid56088300100
dc.authorscopusid38061964200
dc.authorscopusid57200551951
dc.authorscopusid58514211300
dc.authorscopusid7003673004
dc.contributor.authorYıldırım Arslan, Sema
dc.contributor.authorAvcu, Gülhadiye
dc.contributor.authorŞahbudak Bal, Zümrüt
dc.contributor.authorArslan, Asli
dc.contributor.authorÖzkınay, Feristah Ferda
dc.contributor.authorKurugöl, Zafer
dc.date.accessioned2024-08-25T18:36:02Z
dc.date.available2024-08-25T18:36:02Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThe post-COVID-19 syndrome is a new syndrome defined in patients with a history of probable or confirmed SARS-CoV-2 infection, usually within three months of the onset of COVID-19, with symptoms and effects lasting at least 2 months. This study is aimed at comprehensively comparing symptoms of the post-COVID-19 syndrome in children with Delta and Omicron variants. This prospective study included children with COVID-19 followed in hospitalized or outpatient clinics in a tertiary hospital. We used a special questionnaire to ask about the presence of persistent symptoms more than 12 weeks after the initial diagnosis. Patients with positive SARS-CoV-2 PCR were selected randomly and grouped according to the dominant variants in our country at that time as follows: Omicron group (after December 16, 2021); Delta (B.1.617.2) group (August 15, 2021, and December 15, 2021). This study included 200 children, 71 of whom were in the Delta group and 129 of whom were in the Omicron group. Weakness (8.5% vs. 1.6%; p = 0.017), the impact of physical efforts (5.6% vs. 3.9%; p = 0.020), fatigue (22.5% vs. 8.5%; p = 0.009), anxiety disorder (12.7% vs. 0.8%; p = 0.001), and gastrointestinal changes (12.7% vs. 4.7%, p = 0.050) were statistically significantly higher in patients with the Delta variant compared to patients with the Omicron variant. There were no differences between the groups regarding anorexia, anosmia/ageusia, arthralgia, influenza-like symptoms, sleeping disorders, decreased physical activity daily, headache, need for analgesia, concentration and memory disorder, and weight loss (p > 0.05).Conclusion: This study showed that weakness, the impact of physical efforts, fatigue, anxiety disorder, and gastrointestinal changes were more frequent in the Delta group compared to the Omicron group. The incidence of post-COVID-19 syndrome is high in children as well as adults and affects several systems; therefore, it should be kept in mind that children should be followed for post-COVID-19 syndrome.en_US
dc.identifier.doi10.1007/s00431-023-05134-6
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.pmid37526704en_US
dc.identifier.scopus2-s2.0-85166336899en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s00431-023-05134-6
dc.identifier.urihttps://hdl.handle.net/11454/100500
dc.identifier.wosWOS:001041264900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectPost-COVIDen_US
dc.subjectDeltaen_US
dc.subjectOmicronen_US
dc.subjectChildrenen_US
dc.titleEvaluation of post-COVID symptoms of the SARS-CoV-2 Delta and Omicron variants in children: a prospective studyen_US
dc.typeArticleen_US

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