Analysis of saponins and phenolic compounds as inhibitors of ?-carbonic anhydrase isoenzymes

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dc.contributor.authorKoz Ö.
dc.contributor.authorEkinci D.
dc.contributor.authorPerrone A.
dc.contributor.authorPiacente S.
dc.contributor.authorAlankus-Caliskan Ö.
dc.contributor.authorBedir E.
dc.contributor.authorSupuran C.T.
dc.date.accessioned2019-10-27T08:21:40Z
dc.date.available2019-10-27T08:21:40Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractA series of phenolic and saponin type natural products such as quercetin, rutin, catechin, epicatechin, silymarin, trojanoside H, astragaloside IV, astragaloside VIII and astrasieversianin X, were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). We here report inhibitory effects of these compounds against five ?-CA isozymes (hCA I, hCA II, bCA III, hCA IV and hCA VI). Most of the phenolic and saponin type compounds inhibited the isoenzymes quite effectively at low micromolar KI-s ranging between 0.1 and 4 µM, whereas a few derivatives were ineffective (KI-s > 100 µM). The results were remarkable which might lead to design of novel CAIs with a diverse inhibition mechanism compared to sulfonamide/sulfamate inhibitors. © 2013 Informa UK, Ltd.en_US
dc.description.sponsorshipFP7 Ideas: European Research Councilen_US
dc.description.sponsorshipThis study was financed by an FP7 EU grant (Metoxia) to CTS. --en_US
dc.identifier.doi10.3109/14756366.2011.651464en_US
dc.identifier.endpage417en_US
dc.identifier.issn1475-6366
dc.identifier.issue2en_US
dc.identifier.pmid22299585en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage412en_US
dc.identifier.urihttps://doi.org/10.3109/14756366.2011.651464
dc.identifier.urihttps://hdl.handle.net/11454/26080
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectInhibitionen_US
dc.subjectNatural phenolicsen_US
dc.subjectSaponinsen_US
dc.titleAnalysis of saponins and phenolic compounds as inhibitors of ?-carbonic anhydrase isoenzymesen_US
dc.typeArticleen_US

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