Graft Failure and Repeat Penetrating Keratoplasty

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dc.contributor.authorSelver, Ozlem Barut
dc.contributor.authorKaraca, Irmak
dc.contributor.authorPalamar, Melts
dc.contributor.authorEgrilmez, Sait
dc.contributor.authorYagci, Ayse
dc.date.accessioned2021-05-03T20:33:29Z
dc.date.available2021-05-03T20:33:29Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: in this study, we report the indications and outcomes of repeat penetrating keratoplasty and the reasons for graft failure. Materials and Methods: We performed a retrospective data analysis of patients who had undergone 2 or more penetrating keratoplasties for the same eye between 1991 and 2016. Results: Among 1613 penetrating keratoplasties, 149 regrafts of 105 eyes were reviewed. The mean follow-up time after repeat penetrating keratoplasty was 3.2 +/- 3.9 (range, 3 months to 17 years) years. The mean number of penetrating keratoplasties was 2.25 +/- 0.69 per eye (range, 2-6). The most common primary indication for repeat penetrating keratoplasty was bullous keratopathy (31.4%), which was followed by corneal dystrophy (20.0%). The mean follow-up time was 8.05 +/- 5.03 years (range, 8 mo to 24.75 y). At the last follow-up, 62 eyes (59%) had clear grafts and the mean best-corrected visual acuity was 1.26 +/- 0.99 (range, 0-3) logMAR. Endothelial failure, especially late endothelial failure (36.9%), and glaucoma-related endothelial failure (18.8%) were the most common reasons for failed grafts. Allograft rejection (17.4%) and graft infection (14.1%) constituted the next most frequent causes. Conclusions: Graft failure is a common indication among penetrating keratoplasties. Primary indications and reasons for failed grafts affect long-term outcomes. Therefore, a better understanding of the indications for risk, leading causes of failed grafts, and complications could help to determine effective preventive measures.en_US
dc.identifier.doi10.6002/ect.2017.0165en_US
dc.identifier.endpage76en_US
dc.identifier.issn1304-0855
dc.identifier.issn2146-8427
dc.identifier.issue1en_US
dc.identifier.pmid29697353en_US
dc.identifier.scopus2-s2.0-85099902001en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.6002/ect.2017.0165
dc.identifier.urihttps://hdl.handle.net/11454/70046
dc.identifier.volume19en_US
dc.identifier.wosWOS:000605073900012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaskent Univen_US
dc.relation.ispartofExperimental and Clinical Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGraft failureen_US
dc.subjectPenetrating keratoplastyen_US
dc.subjectRepeat penetrating keratoplastyen_US
dc.titleGraft Failure and Repeat Penetrating Keratoplastyen_US
dc.typeArticleen_US

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