Biochemical markers in cartilage injury and repair [Kikirdak yaralanmasi ve onariminda biyokimyasal belirteçler.]
Küçük Resim Yok
Tarih
2007
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Articular cartilage is a highly specialized tissue composed of chondrocytes which regulate the metabolism of extracellular matrix molecules responsible for maintaining cartilage function. Chondrocytes and synoviocytes are metabolically highly active cells and respond to various factors such as hormones, cytokines, growth factors, and mechanical stresses. Under normal physiological conditions, degradation and synthesis of extracellular matrix molecules are maintained in a state of balance. Any disruption of this balance results in degenerative cartilage diseases such as osteoarthritis and rheumatoid arthritis. Currently, diagnoses of both diseases are based on the assessment of a combination of clinical symptoms and radiological findings. However, degenerative changes in the articular cartilage occurs long before radiological changes are observed. Therefore, new laboratory tools are required to detect cartilage degradation in the early phase of the disease, to show the progression of cartilage destruction, and to assess response to treatment. In recent years, there has been an increase in the use of some biochemical markers derived from bone and cartilage for the diagnosis and follow-up of cartilage diseases. In this paper, the utility of these markers for early diagnosis and follow-up of cartilage injury is discussed in the light of the current literature.
Açıklama
Anahtar Kelimeler
Kaynak
Acta orthopaedica et traumatologica turcica
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
41 Suppl 2
