A novel SPECT/MRI bimodal imaging probe: Tc-99m-DPAPA-Fe3O4 nanoconjugate

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dc.authoridYasakci, Volkan/0000-0002-4133-3886
dc.authorscopusid57204160728
dc.authorscopusid57241222300
dc.authorscopusid57216968604
dc.authorscopusid55668684600
dc.authorscopusid7003859320
dc.contributor.authorYasakci, Volkan
dc.contributor.authorTutun, Elif
dc.contributor.authorKaratay, Kadriye Busra
dc.contributor.authorAras, Omer
dc.contributor.authorUnak, Perihan
dc.date.accessioned2024-08-25T18:32:45Z
dc.date.available2024-08-25T18:32:45Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study aimed to create a novel bimodal probe. For this purpose, cubic iron oxide nanoparticles (C-Fe3O4 NPs) conjugated with an EDTMP derivative called DPAPA thought to be a targeting tool for prostate cancer and bone metastases were studied. NPs were synthesized and conjugated with DPAPA, and then characterization studies were carried out. The particles were demonstrated to be cubic shaped, with an average size of 68.55 +/- 1 0.03 (n = 3) nm. Then the nanoconjugates were radiolabeled with Tc-99m. In vitro cellular affinities were conducted using PC-3, RWPE-1, LNCaP, K562, and Saos-2 cell lines. In conclusion, radio-nanoconjugates have the potential for bimodal MRI/SPECT imaging.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey) [218S749]; 100/2000 CoHE Doctorate Scholarship (YOEK) 100/2000 Scholarship; Turkish Higher Education Council (YOEK); NIH/NCI Cancer Support Grant [P30 CA008748]; Turkish Higher Education Council (YOEK) 100/2000 CoHE Ph.D.en_US
dc.description.sponsorshipThis work was supported financially by TUBITAK (The Scientific and Technological Research Council of Turkey) within the scope of the Bilateral Cooperation Project No. 218S749. The authors thank TUBITAK for the support. Volkan Yasakci was also supported through the 100/2000 CoHE Doctorate Scholarship and Turkish Higher Education Council (YOEK) 100/2000 Scholarship. The authors thank the Turkish Higher Education Council (YOEK) and 100/2000 CoHE Ph.D. for their support. Dr. Omer Aras was partially supported through the NIH/NCI Cancer Support Grant P30 CA008748. The work was partially presented at the International Conference on Clinical PET-CT and Molecular Imaging in the Era of Theranostics, IPET-2020, IAEA-CN-285/52, and the International Nuclear Sciences and Technologies Conference (INSTEC-22).en_US
dc.identifier.doi10.1007/s10967-023-08875-8
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.scopus2-s2.0-85151537010en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-023-08875-8
dc.identifier.urihttps://hdl.handle.net/11454/100332
dc.identifier.wosWOS:000962995200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectCubic iron oxide nanoparticlesen_US
dc.subjectHyperbranched polyglycerolen_US
dc.subject(S)-2en_US
dc.subject5-Bis(bis(phosphonomethyl)amino) pentanoic aciden_US
dc.subjectTc-99men_US
dc.subjectProstate cancer cellsen_US
dc.subjectSPECTen_US
dc.subjectMRI probeen_US
dc.subjectMagnetic Nanoparticlesen_US
dc.subjectIn-Vitroen_US
dc.subjectBreast-Canceren_US
dc.subjectMrien_US
dc.subjectMetastasesen_US
dc.subjectCellsen_US
dc.titleA novel SPECT/MRI bimodal imaging probe: Tc-99m-DPAPA-Fe3O4 nanoconjugateen_US
dc.typeArticleen_US

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