A novel SPECT/MRI bimodal imaging probe: Tc-99m-DPAPA-Fe3O4 nanoconjugate
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study aimed to create a novel bimodal probe. For this purpose, cubic iron oxide nanoparticles (C-Fe3O4 NPs) conjugated with an EDTMP derivative called DPAPA thought to be a targeting tool for prostate cancer and bone metastases were studied. NPs were synthesized and conjugated with DPAPA, and then characterization studies were carried out. The particles were demonstrated to be cubic shaped, with an average size of 68.55 +/- 1 0.03 (n = 3) nm. Then the nanoconjugates were radiolabeled with Tc-99m. In vitro cellular affinities were conducted using PC-3, RWPE-1, LNCaP, K562, and Saos-2 cell lines. In conclusion, radio-nanoconjugates have the potential for bimodal MRI/SPECT imaging.
Açıklama
Anahtar Kelimeler
Cubic iron oxide nanoparticles, Hyperbranched polyglycerol, (S)-2, 5-Bis(bis(phosphonomethyl)amino) pentanoic acid, Tc-99m, Prostate cancer cells, SPECT, MRI probe, Magnetic Nanoparticles, In-Vitro, Breast-Cancer, Mri, Metastases, Cells
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
