Thalassemia-free and graft-versus-host-free survival: outcomes of hematopoietic stem cell transplantation for thalassemia major, Turkish experience

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dc.authoridkartal, ibrahim/0000-0002-2772-9956
dc.authoridKüpeli, Serhan/0000-0001-7271-1803
dc.authoriduygun, vedat/0000-0003-3257-7798
dc.authoridOk Bozkaya, Ikbal/0000-0002-7666-8731
dc.authoridAtay, Didem/0000-0003-3040-1959
dc.authoridkaragun, barbaros sahin/0000-0002-7678-5524
dc.authoridHazar, Volkan/0000-0002-1407-2334
dc.authorscopusid57219410481
dc.authorscopusid10043117000
dc.authorscopusid8314098500
dc.authorscopusid27267680800
dc.authorscopusid7005581623
dc.authorscopusid7003650841
dc.authorscopusid6603486378
dc.authorwosidYalcin, Koray/AGD-9441-2022
dc.authorwosidkartal, ibrahim/AAA-5354-2021
dc.authorwosidARMAN BİLİR, Özlem/HFZ-8242-2022
dc.authorwosidKüpeli, Serhan/J-1588-2014
dc.authorwosiduygun, vedat/AGH-4534-2022
dc.authorwosidOk Bozkaya, Ikbal/P-4121-2015
dc.authorwosidAtay, Didem/A-8647-2019
dc.contributor.authorYesilipek, M. Akif
dc.contributor.authorUygun, Vedat
dc.contributor.authorKupesiz, Alphan
dc.contributor.authorKarasu, Gulsun
dc.contributor.authorOzturk, Gulyuz
dc.contributor.authorErtem, Mehmet
dc.contributor.authorSasmaz, Ilgen
dc.date.accessioned2023-01-12T19:58:38Z
dc.date.available2023-01-12T19:58:38Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractWe report the national data on the outcomes of hematopoietic stem cell transplantation (HSCT) for thalassemia major (TM) patients in Turkey on behalf of the Turkish Pediatric Stem Cell Transplantation Group. We retrospectively enrolled 1469 patients with TM who underwent their first HSCT between 1988 and 2020 in 25 pediatric centers in Turkey. The median follow-up duration and transplant ages were 62 months and 7 years, respectively; 113 patients had chronic graft versus host disease (cGVHD) and the cGVHD rate was 8.3% in surviving patients. Upon the last visit, 30 patients still had cGvHD (2.2%). The 5-year overall survival (OS), thalassemia-free survival (TFS) and thalassemia-GVHD-free survival (TGFS) rates were 92.3%, 82.1%, and 80.8%, respectively. cGVHD incidence was significantly lower in the mixed chimerism (MC) group compared to the complete chimerism (CC) group (p < 0.001). In survival analysis, OS, TFS, and TGFS rates were significantly higher for transplants after 2010. TFS and TGFS rates were better for patients under 7 years and at centers that had performed over 100 thalassemia transplants. Transplants from matched unrelated donors had significantly higher TFS rates. We recommend HSCT before 7 years old in thalassemia patients who have a matched donor for improved outcomes.en_US
dc.description.sponsorshipTurkish Society of Pediatric Hematologyen_US
dc.description.sponsorshipWe would like to thank Vedat Uygun for contributing to the statistics of the study. This study was supported by the Turkish Society of Pediatric Hematology.en_US
dc.identifier.doi10.1038/s41409-022-01613-w
dc.identifier.endpage767en_US
dc.identifier.issn0268-3369
dc.identifier.issn1476-5365
dc.identifier.issue5en_US
dc.identifier.pmid35210564en_US
dc.identifier.scopus2-s2.0-85125139401en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage760en_US
dc.identifier.urihttps://doi.org/10.1038/s41409-022-01613-w
dc.identifier.urihttps://hdl.handle.net/11454/76977
dc.identifier.volume57en_US
dc.identifier.wosWOS:000761872800003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBone Marrow Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone-Marrow-Transplantationen_US
dc.subjectCord Blood Transplantationen_US
dc.subjectLong-Termen_US
dc.subjectChildrenen_US
dc.subjectDiseaseen_US
dc.subjectDonoren_US
dc.titleThalassemia-free and graft-versus-host-free survival: outcomes of hematopoietic stem cell transplantation for thalassemia major, Turkish experienceen_US
dc.typeArticleen_US

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