Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]

Küçük Resim Yok

Tarih

2014

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Elsevier Inc.

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac = saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2].H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity. © 2014 Elsevier B.V. All rights reserved.

Açıklama

Anahtar Kelimeler

Ammine, Anti-cancer, Cisplatin, Saccharinate, Thiosaccharinate, X-ray structure

Kaynak

Journal of Inorganic Biochemistry

WoS Q Değeri

Scopus Q Değeri

Q1

Cilt

141

Sayı

1

Künye