Serum nerve growth factor levels in autistic children in Turkish population: A preliminary study

Basit Öğe Kaydı
dc.contributor.authorDincel, Nida
dc.contributor.authorUnalp, Aycan
dc.contributor.authorKutlu, Ayse
dc.contributor.authorOzturk, Aysel
dc.contributor.authorUran, Nedret
dc.contributor.authorUlusoy, Sadik
dc.date.accessioned2019-10-27T22:06:39Z
dc.date.available2019-10-27T22:06:39Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground & objectives: It has been hypothesized that abnormal levels of serum nerve growth factor (NGF) may represent a serological marker for autistic children who may develop cognitive impairment, regression and finally epilepsy. The objective of this preliminary study was to measure serum NGF concentrations of autistic children and compare these levels with those of healthy children. Methods: Consecutive children who were referred to the Paediatric Neurology and Child Psychiatry Policlinics of Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Turkey between February and September 2008 were included in the study. Serum samples were analyzed for NGF levels using ChemiKine NGF Sandwich ELISA Kit. Comparisons between the study and the control groups were made using student's t test and Chi-square test. Results: Forty-nine autistic children and an equal number of healthy children (control group) were included in the study. No significant difference was found between the study and the control groups in terms of children's age, while number of boys was significantly higher (P<0.05) in the study group. Average serum NGF concentrations were 46.94 +/- 51.40 and 32.94 +/- 12.48 pg/ml in the study and control group, respectively. Serum NGF concentrations were significantly higher (P<0.05) in the study group compared with the control group. Interpretation & conclusions: Our preliminary findings show that enhanced serum NGF concentration may be used as a potential diagnostic tool in autism, however, further studies including a large number of patients are required to confirm the findings.en_US
dc.identifier.endpage903en_US
dc.identifier.issn0971-5916
dc.identifier.pmid24521633en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage900en_US
dc.identifier.urihttps://hdl.handle.net/11454/48853
dc.identifier.volume138en_US
dc.identifier.wosWOS:000330879500016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIndian Council Medical Resen_US
dc.relation.ispartofIndian Journal of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutismen_US
dc.subjectchilden_US
dc.subjectepilepsyen_US
dc.subjectnerve growth factoren_US
dc.subjectneurodevelopmenten_US
dc.titleSerum nerve growth factor levels in autistic children in Turkish population: A preliminary studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu