A new antimalarial quassinoid from Simaba orinocensis
| dc.contributor.author | Muhammad I. | |
| dc.contributor.author | Bedir E. | |
| dc.contributor.author | Khan S.I. | |
| dc.contributor.author | Tekwani B.L. | |
| dc.contributor.author | Khan I.A. | |
| dc.contributor.author | Takamatsu S. | |
| dc.contributor.author | Pelletier J. | |
| dc.contributor.author | Walker L.A. | |
| dc.date.accessioned | 2019-10-27T00:23:04Z | |
| dc.date.available | 2019-10-27T00:23:04Z | |
| dc.date.issued | 2004 | |
| dc.department | Ege Üniversitesi | en_US |
| dc.description.abstract | A new antimalarial quassinoid, namely, orinocinolide (1), was isolated from the root bark of Simaba orinocensis, together with the previously reported simalikalactone D (2). The structure of 1 was determined primarily from 1D and 2D NMR analysis, as well as by chemical derivatization. Compound 1 was found to be as equally potent as 2 against Plasmodium falciparum clones D6 and W2 (IC50 3.27 and 8.53 ng/ mL vs 3.0 and 3.67 ng/mL, respectively), but was 4- and 28-fold less toxic than 2 against VERO cells (IC50 10 vs 2.3 µg/mL) and HL-60 (IC50 0.7 vs 0.025 µg/mL), respectively. In addition, 2 was >46- and >31-fold more potent than pentamidine and amphotericin B (IC50 0.035 vs 1.6 and 1.1 µg/mL) against Leishmania donovani, while 1 was inactive. Orinocinolide (1) inhibited growth of human cancer cells SK-MEL, KB, BT-549, and SK-OV-3, but was less potent than 2 (IC50 0.8-1.9 vs 0.3-1.0 µg/mL) against these cells. | en_US |
| dc.identifier.doi | 10.1021/np030524n | en_US |
| dc.identifier.endpage | 777 | en_US |
| dc.identifier.issn | 0163-3864 | |
| dc.identifier.issue | 5 | en_US |
| dc.identifier.pmid | 15165136 | en_US |
| dc.identifier.scopusquality | Q1 | en_US |
| dc.identifier.startpage | 772 | en_US |
| dc.identifier.uri | https://doi.org/10.1021/np030524n | |
| dc.identifier.uri | https://hdl.handle.net/11454/22717 | |
| dc.identifier.volume | 67 | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.indekslendigikaynak | PubMed | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.relation.ispartof | Journal of Natural Products | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | A new antimalarial quassinoid from Simaba orinocensis | en_US |
| dc.type | Article | en_US |
