Subacute Sclerosing Panencephalitis Cases Diagnosed by Increased CSF/Serum Measles Antibody Indices

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dc.contributor.authorSamlioglu, Pinar
dc.contributor.authorUnalp, Aycan
dc.contributor.authorGokcay, Ahmet
dc.contributor.authorAltuglu, Imre
dc.contributor.authorOzturk, Aysel
dc.contributor.authorZeytinoglu, Aysin
dc.date.accessioned2019-10-27T21:41:01Z
dc.date.available2019-10-27T21:41:01Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractSubacute sclerosing panencephalitis (SSPE) caused by persistent defective measles virus strains, is a progressive neurological disorder of children and adolescents. The aim of this letter was to share the data from SSPE-suspected cases who were definitely diagnosed by the detection of increased antibody index in serum and cerebrospinal fluid (CSF) samples. A total of 11 patients (mean age: 14.3 years) with suspected SSPE between February 2006 to August 2008, were included in the study. Simultaneously obtained serum and CSF samples from patients were analyzed in terms of albumin, total IgG and measles-specific IgG levels (Measles Virus IgG ELISA for CSF Diagnostics, Euroimmun, Germany). The value of CSQ(rel) (relative CSF/serum quotient) >= 1.5 was accepted indicative for intrathecal measles antibody synthesis. Seven (63.6%) of the 11 patients' diagnosis were confirmed with the demonstration of elevated CSF/serum indices (CSQ(rel), range: 2.3-36.9; mean: 12.9). Mean age of those seven cases was 12.3 years (age range: 7-21) and four of them were male. The history of patients with high antibody indices indicated that three of four patients who had measles infection had not been vaccinated against measles. These three unvaccinated patients had measles infection at 3rd, 8th and 30th months of age, respectively, and the period of SSPE development were 15, 6 and 4.5 years, respectively. With this letter we would like to emphasize once more that effective measles vaccination is the only way for the prevention of measles and SSPE and the demonstration of increased measles antibody index in simultaneously obtained serum and CSF samples is crucial for the diagnosis of SSPE.en_US
dc.identifier.endpage718en_US
dc.identifier.issn0374-9096
dc.identifier.issue4en_US
dc.identifier.pmid23188587en_US
dc.identifier.startpage716en_US
dc.identifier.urihttps://hdl.handle.net/11454/46501
dc.identifier.volume46en_US
dc.identifier.wosWOS:000311330900022en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherAnkara Microbiology Socen_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSubacute sclerosing panencephalitisen_US
dc.subjectmeasles virusen_US
dc.subjectantibody indexen_US
dc.subjectserodiagnosisen_US
dc.titleSubacute Sclerosing Panencephalitis Cases Diagnosed by Increased CSF/Serum Measles Antibody Indicesen_US
dc.typeLetteren_US

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