Comparison of the C14 urea breath test and histopathology in the diagnosis of helicobacter pylori in the elderly

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dc.contributor.authorAtli, Teslime
dc.contributor.authorSahin, Sevnaz
dc.contributor.authorArslan, Bilge Ugur
dc.contributor.authorVarli, Murat
dc.contributor.authorYalcin, Ahmet Emre
dc.contributor.authorAras, Sevgi
dc.date.accessioned2019-10-27T21:41:06Z
dc.date.available2019-10-27T21:41:06Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: To compare the sensitivity and specificity of C[14] urea breath test with histopathological findings in biopsies obtained through endoscopy. Methods: In this cross-sectional study, conducted at the Medical Faculty Ankara University, Ankara, Turkey between January and October 2009, 100 patients aged 65 and above who fulfilled the criteria for inclusion were enrolled. Oesophago-gastroduodenoscopy was carried out on the patients after eight hours of fasting, using a Fujinon endoscope, by the same expert. C-14 urea breath tests were carried out on all patients with a capsule containing 37 kBq(1 mu Ci) C-14 urea/citric acid. Evaluation of all data was carried out using SPSS 11.5. Categorical variables were compared through Pearson Chi squared or Fisher's exact test. P<0.005 was taken as statistically significant. Results: The average age of the patients was 71 +/- 5 years; 43 (43%) were male; and 57 (57%) were female. Helicobacter pylon positivity was found to be 35 (35%) in histopathological evaluation, and 36 (36%) in the C-14 urea breath test. Of the 35 patients, 32 (91.4%) were found to be positive by the C-14 urea breath test also. Of the 65 patients who were found to be negative on histopathology, 61(93.8%) were also found to be Hp negative by the C-14 urea breath test, and 4 (6.2%) were evaluated as false positive. A statistically significant correlation (p<0.001) was found between histopathological and C-14 urea breath test results. Compared with histopathology, the sensitivity of the urea breath test was 91.4%, and its specificity was 93.8%. A statistically significant (p <0.001) relationship was found between histopathological results and the results of the C-14 urea breath test. Conclusion: The sensitivity and specificity of the C[14] urea breath test in the group of elderly patients selected was high. The C-14 urea breath test can be considered in the elderly group for diagnosis of Helicobacter pylori infection.en_US
dc.identifier.endpage1065en_US
dc.identifier.issn0030-9982
dc.identifier.issue10en_US
dc.identifier.pmid23866448en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1061en_US
dc.identifier.urihttps://hdl.handle.net/11454/46541
dc.identifier.volume62en_US
dc.identifier.wosWOS:000309100200018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPakistan Medical Assocen_US
dc.relation.ispartofJournal of the Pakistan Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUrea breath testen_US
dc.subjectHistopathologicalen_US
dc.subjectHelicobacter pylori infectionen_US
dc.titleComparison of the C14 urea breath test and histopathology in the diagnosis of helicobacter pylori in the elderlyen_US
dc.typeArticleen_US

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