Polymeric Thioxanthones as Potential Anticancer and Radiotherapy Agents

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dc.contributor.authorYilmaz, Gorkem
dc.contributor.authorGuler, Emine
dc.contributor.authorBarlas, Firat Baris
dc.contributor.authorTimur, Suna
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T23:09:17Z
dc.date.available2019-10-27T23:09:17Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractThioxanthone (TX) and its derivatives, which are widely used as photoinitiators in UV curing technology, hold promising research interest in biological applications. In particular, the use of TXs as anticancer agent has recently been manifested as an outstanding additional property of this class of molecules. Incorporation of TX molecules into specially designed polymers widens their practical use in such applications. In this study, two water-soluble, biocompatible, and stable polymers, namely poly(vinyl alcohol) and poly(ethylene glycol), possessing TX moieties at the side chains and chain ends, respectively, are prepared and used as anticancer and radiotherapy agents. The findings confirm that both polymers are potential candidates for therapeutic agents as they possess useful features including water-solubility, radiosensitizer effect, and anticancer activity in a polymeric scaffold.en_US
dc.identifier.doi10.1002/marc.201600189en_US
dc.identifier.endpage1051en_US
dc.identifier.issn1022-1336
dc.identifier.issn1521-3927
dc.identifier.issue13en_US
dc.identifier.pmid27168378en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1046en_US
dc.identifier.urihttps://doi.org/10.1002/marc.201600189
dc.identifier.urihttps://hdl.handle.net/11454/52592
dc.identifier.volume37en_US
dc.identifier.wosWOS:000380008400006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofMacromolecular Rapid Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanticanceren_US
dc.subjectcytotoxicityen_US
dc.subjectpoly(ethylene glycol)en_US
dc.subjectpoly(vinyl alcohol)en_US
dc.subjectradiotherapyen_US
dc.subjectthioxanthonesen_US
dc.titlePolymeric Thioxanthones as Potential Anticancer and Radiotherapy Agentsen_US
dc.typeArticleen_US

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