Could Retroperitoneal Ganglioneuroma be a Dopamine Secreting Ganglioneuroma?

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dc.contributor.authorOzisik, Hatice
dc.contributor.authorYurekli, Banu Sarer
dc.contributor.authorKutbay, Nilufer Ozdemir
dc.contributor.authorEker, Baris
dc.contributor.authorErtan, Yesim
dc.contributor.authorSaygili, Fusun
dc.date.accessioned2019-10-27T10:45:46Z
dc.date.available2019-10-27T10:45:46Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractGanglioneuromas are rarely occurring benign tumors characterized by hyperplasia of mature ganglia and satellite cells. They are well-differentiated, slow growing, and autonomous nervous system neoplasms, which are usually asymptomatic and do not release any hormones. A male patient aged 26 years was evaluated for secondary hypertension six months ago. Ultrasonography of the abdomen revealed a mass lesion around the right kidney. An analysis of the 24-hour urine sample of the patient revealed the following parameters: 5-HIAA=3.9 mg/day (2-7), metanephrine=56.3 mu g/day (52-341), and normetanephrine=146.1 mu g/day (88-444). The computed tomography scan of the abdomen showed a retroperitoneal mass of 10 cm in size, containing minute calcified foci in the right retroperitoneal region. The mass was excised through general surgery and was classified as ganglioneuroma. The blood pressure of the patient returned to normal level after surgery, and he needed no further antihypertensive treatment. Besides, the metanephrine and normetanephrine levels in the 24-hour urine were also observed to be normal as in the preoperative period. Retroperitoneal masses can actually be ganglioneuromas and an accurate diagnosis can be achieved only through postoperative histopathological evaluation. After the operation, blood pressure of the patient returned to normal. This suggests that retroperitoneal ganglioneuroma could possibly secrete dopamine, epinephrine, or norepinephrine.en_US
dc.identifier.doi10.25179/tjem.2017-56509
dc.identifier.endpage101en_US
dc.identifier.issn1301-2193
dc.identifier.issue2en_US
dc.identifier.startpage98en_US
dc.identifier.urihttps://doi.org/10.25179/tjem.2017-56509
dc.identifier.urihttps://hdl.handle.net/11454/31200
dc.identifier.volume22en_US
dc.identifier.wosWOS:000435845900008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRetroperitoneal ganglioneuromaen_US
dc.subjecthypertensionen_US
dc.subjectcatecholamineen_US
dc.titleCould Retroperitoneal Ganglioneuroma be a Dopamine Secreting Ganglioneuroma?en_US
dc.typeArticleen_US

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