Factors effecting natural course of egg allergy

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dc.authoridTOPYILDIZ, Ezgi/0000-0002-9260-8157
dc.contributor.authorSenol, Handan Duman
dc.contributor.authorGeyik, Mehmet
dc.contributor.authorTopyldz, Ezgi
dc.contributor.authorAygun, Ayse
dc.contributor.authorGulen, Figen
dc.contributor.authorDemir, Esen
dc.date.accessioned2024-08-31T07:48:10Z
dc.date.available2024-08-31T07:48:10Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground. There is limited data about the natural course of egg allergy in the literature. We aimed to analyze the factors that can affect the tolerance or persistence of egg allergy. Methods. A total number of 126 IgE-mediated egg allergic patient who had data about tolerance gaining were included in the study. Demographic and laboratory data were recorded retrospectively. Kaplan -Meier curves was used for estimation of resolution and the factors related to resolution by Cox regression model. Results. Among 126 patients, 81 (64.2%) had gained tolerance with a median survival time of 48 months (min: 12 -max: 121). Tolerance was gained in 22.2% (n = 28) of these patients in the first 2 years of life, in 46.8% (n = 49) in 2-6 years, 3.1% (n = 4) between 7-12 years. In univariate analysis, baseline sIgE level was < 8.2 (Hazard ratio: 2.193; 95%CI 1.309-3.674; p = 0.003), no history of anaphylaxis (at initiation or during OFC) (Hazard ratio: 11.292; 95%CI 2.766-46.090; p = 0.001) and baseline egg SPT < 11 mm (Hazard ratio: 2.906; 95%CI 1.424-5.930, p = 0.003) were found to be related to earlier resolution of egg allergy. In multivariate analysis, only anaphylaxis was significantly related to later resolution (Hazard ratio: 6.547; 95%CI 15.8027.434; p = 0.01). Conclusions. Higher levels of egg sIgE, skin prick test induration and anaphylaxis at onset or during oral food challenge, can give hint about persistence of egg allergy.en_US
dc.identifier.doi10.23822/EurAnnACI.1764-1489.287
dc.identifier.endpage120en_US
dc.identifier.issn1764-1489
dc.identifier.issue3en_US
dc.identifier.pmid36891735en_US
dc.identifier.scopus2-s2.0-85194863521en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage116en_US
dc.identifier.urihttps://doi.org/10.23822/EurAnnACI.1764-1489.287
dc.identifier.urihttps://hdl.handle.net/11454/104690
dc.identifier.volume56en_US
dc.identifier.wosWOS:001235085300003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdra Spaen_US
dc.relation.ispartofEuropean Annals of Allergy and Clinical Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectEgg Allergyen_US
dc.subjectEgg Specific Igeen_US
dc.subjectSkin Prick Test Indurationen_US
dc.subjectPersistenceen_US
dc.subjectToleranceen_US
dc.titleFactors effecting natural course of egg allergyen_US
dc.typeArticleen_US

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