Effect of prolonged administration of bovine lactoferrin in neuropathic pain: Involvement of opioid receptors, nitric oxide and TNF-?

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dc.contributor.authorÖnal A.
dc.contributor.authorKayalioglu G.
dc.contributor.authorParlar A.
dc.contributor.authorKeser A.
dc.contributor.authorÜlker S.
dc.date.accessioned2019-10-26T22:44:49Z
dc.date.available2019-10-26T22:44:49Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractAims: This study aimed to investigate the effect of prolonged administration of bovine milk lactoferrin (bLF) on hyperalgesia and allodynia in a rat model of neuropathic pain and to determine the involvement of c-Fos, TNF-?, nitric oxide and opioidergic systems in this effect. Main methods: Neuropathic pain was induced in rats by loose ligation of the right sciatic nerve and evaluated by tests measuring the mechanical and thermal hyperalgesia and allodynia. bLF (50, 100, and 200 mg/kg) alone or in combination with opioidergic antagonists were administered intraperitoneally to the rats with neuropathic pain c-Fos and NADPH-d immunocytochemistry and Western blotting for TNF-?, iNOS and nNOS were performed in the lumbar spinal cord of rats. Plasma TNF-? levels were determined with ELISA. Key findings: Prolonged, but not single, administration of bLF produced antihyperalgesic and antiallodynic effects in neuropathic rats. Pretreatment with opioidergic antagonists significantly decreased this effect. Prolonged administration of bLF decreased c-Fos and NADPH-d immunoreactivity and TNF-? and iNOS expressions at 50 and 100 mg/kg and nNOS expression at 100 mg/kg in the lumbar spinal cord of neuropathic rats. Plasma TNF-? levels remained unchanged after bLF treatment. Significance: Prolonged administration of bLF exerts antihyperalgesic and antiallodynic effect in neuropathic rats; down-regulation of both TNF-? and iNOS expressions and potentiation of opioidergic system in the lumbar spinal cord can contribute to this effect. © 2010 Elsevier Inc.en_US
dc.description.sponsorshipYoung Researchers and Elite Club 104S287en_US
dc.description.sponsorshipThis investigation was supported by the National Young Researchers Career Development Programme (Career Programme) of The Scientific and Technological Research Council of Turkey (Project no: 104S287 ). We wish to thank Semra Kahraman and Fatma Gül Çelenk for their technical assistance. --en_US
dc.identifier.doi10.1016/j.lfs.2009.12.007en_US
dc.identifier.endpage259en_US
dc.identifier.issn0024-3205
dc.identifier.issue07.Augen_US
dc.identifier.pmid20045006en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2009.12.007
dc.identifier.urihttps://hdl.handle.net/11454/20068
dc.identifier.volume86en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLactoferrinen_US
dc.subjectMononeuropathyen_US
dc.subjectNitric oxide synthaseen_US
dc.subjectPainen_US
dc.subjectRaten_US
dc.subjectTumor necrosis factor alphaen_US
dc.titleEffect of prolonged administration of bovine lactoferrin in neuropathic pain: Involvement of opioid receptors, nitric oxide and TNF-?en_US
dc.typeArticleen_US

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