Investigation of class-d beta-lactamases causing carbapenem resistance in clinical Acinetobacter baumannii isolates*

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dc.contributor.authorDavandeh, Iskandar
dc.contributor.authorEraç, Bayrı
dc.contributor.authorAydemir, Sabire Şöhret
dc.date.accessioned2020-12-01T12:29:31Z
dc.date.available2020-12-01T12:29:31Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/aim: Acinetobacter baumannii is an important causative agent of nosocomial infections, and carbapenems have been frequently used in the treatment of these infections. This study was designed to investigate the prevalence of primary carbapenem hydrolyzing oxacillinase (CHO) types in clinical A. bumannii strains. Materials and methods: Minimum inhibitory concentration (MIC) values of 76 imipenem nonsusceptible A. baumannii strains, isolated from a tertiary care hospital, were determined by microdilution method. the clonal relationship of the isolates was analyzed with enterobacterial repetitive intergenic consensus (ERIC)-PCR, and the presence of CHO major groups (OXA-23; OXA-24, OXA-51, and OXA-58 groups) was investigated with multiplex PCR. Results: According to the ERIC-PCR patterns, the isolates were distributed in 13 different clones, the largest of which had 40 members. blaOXA-51-groupwas detected in representatives of all clones, whereas blaOXA-23-groupwas detectedin representatives of all but two small clones. Additionally, the presence of blaOXA-58-groupwas discovered in the members of two small clones, whereas blaOXA-24-groupwas not encountered in any of the examined strains. Conclusion: Molecular fingerprinting revealed that most imipenem-resistant A. baumannii strains were clonally related. blaOXA-23-group and blaOXA-51-groupwere mostly responsible for the imipenem resistance of the examined A. baumannii strains.en_US
dc.identifier.endpage1666en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.startpage1661en_US
dc.identifier.urihttps://app.trdizin.gov.tr//makale/TWpVME5qUTFOUT09
dc.identifier.urihttps://hdl.handle.net/11454/65946
dc.identifier.volume47en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleInvestigation of class-d beta-lactamases causing carbapenem resistance in clinical Acinetobacter baumannii isolates*en_US
dc.typeArticleen_US

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