Long-term treatment with acarbose for the treatment of reactive hypoglycemia
Küçük Resim Yok
Tarih
1998
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Acarbose, a potent alpha-glucosidase inhibitor, provides a new Concept for the treatment of metabolic disorders, and particularly diabetes mellitus. It reduces the postprandial blood glucose increment and insulin response. For this reason the drug has been successfully used not only in the treatment of type 1 and type 2 diabetes, but also in the management of reactive hypoglycemia and dumping syndrome. The primary aim of the present study is to evaluate the long-term effect of acarbose in reducing hypoglycemic symptoms and influencing laboratory measurements in patients with the diagnosis of hypoglycemia. Design and Methods: 21 non-obese (BM1 < 27 kg/m2) patients(6 males, 15 females) complaining of postprandial symptoms suggesting hypoglycemia and who showed blood glucose values of <54 mg/dl on one or more occasions during a 5 h oral glucose toler ance test (OGTT) were selected. Results: Before treatment, ingestion of glucose decreased plasma glucose levels at the 3rd and 4th hours, the lowest levels being 39 mg/dl and 45 mg/dl respectively. Eighteen patients had hypoglycemic symptoms during OGTT. Follwing 3 months of acarbose treatment, the lowest plasma glucose levels at the 3rd and 4th hours increased to 67 mg/dl and 75 mg/dl respectively. Plasma insulin and c-peptide levels 1 were reduced between the 1st and 5th hours, but only the 1st and 2nd hour decrements were statistically significant. The area under the curve (AUC) between 0-300 minutes for insulin was not significant. Plasma glucose levels were significantly increased during the last 3 hours The AUC for glucose was not significantly changed. Frequency of hypoglycemic attacks was reduced from 4 times a week to 1. C-peptide levels in 24-hour urine collection did not change significantly: 45 ug/I and 56 pgA respectively before and after treatment. Conclusions: These results confirm that acarbose may be of value in preventing reactive hypoglycemia by reactive ing the early hyperglycemic stimulus to insulin secretion, and in the treatment of hypoglycemia.
Açıklama
Anahtar Kelimeler
Acarbose, Reactive hypoglycemia
Kaynak
Eating and Weight Disorders
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
3
Sayı
3
