Ruthenium (II) complexes of thiosemicarbazone: Synthesis, biosensor applications and evaluation as antimicrobial agents

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dc.contributor.authorYildirim, Hatice
dc.contributor.authorGuler, Emine
dc.contributor.authorYavuz, Murat
dc.contributor.authorOzturk, Nurdan
dc.contributor.authorYaman, Pelin Kose
dc.contributor.authorSubasi, Elif
dc.contributor.authorSahin, Elif
dc.contributor.authorTimur, Suna
dc.date.accessioned2019-10-27T22:12:35Z
dc.date.available2019-10-27T22:12:35Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractA conformationally rigid half-sandwich organoruthenium (II) complex [(eta(6)-p-cymene)RuClTSCN-S]Cl, (1) and carbonyl complex [Ru(CO)Cl(PPh3)(2)TSCN-S] (2) have been synthesized from the reaction of [{(eta(6)-p-cymene) RuCl}(2)(mu-Cl)(2)] and [Ru(H)(Cl)(CO)(PPh3)(3)] with thiophene-2-carboxaldehyde thiosemicarbazon (TSC) respectively and both novel ruthenium (II) complexes have been characterized by elemental analysis, FT-IR and NMR spectroscopy. The peripheral TSC in the complexes acts as an electrochemical coupling unit providing the ability to carry out electrochemical deposition (ED) and to form an electro-deposited film on a graphite electrode surface. The biosensing applicability of complexes 1 and 2 was investigated by using glucose oxidase (GOx) as a model enzyme. Electrochemical measurements at -0.9 V versus Ag/AgCl electrode by following the ED Ru(II) reduction/oxidation due to from the enzyme activity, in the presence of glucose substrate. The designed biosensor showed a very good linearity for 0.01-0.5 mM glucose. The in vitro antimicrobial activities of complexes 1 and 2 were also investigated against nine bacterial strains and one fungus by the disc diffusion test method. No activity was observed against the Gram-negative strains and fungus, whereas complex 1 showed moderate antibacterial activities against Gram-positive bacterial strains. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipDokuz Eylul University Rectorship, Scientific Research Project Coordination CenterDokuz Eylul University [2011.KB.FEN.047, 2012.KB.FEN.047]en_US
dc.description.sponsorshipThis study was supported by project number 2011.KB.FEN.047 and 2012.KB.FEN.047 from Dokuz Eylul University Rectorship, Scientific Research Project Coordination Center. We also thank the Graduate School of Natural and Applied Sciences, Dokuz Eylul University, EBILTEM, Ege University for NMR analysis and TUBITAK, for the elemental analysis.en_US
dc.identifier.doi10.1016/j.msec.2014.08.007en_US
dc.identifier.endpage8en_US
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid25280673en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.msec.2014.08.007
dc.identifier.urihttps://hdl.handle.net/11454/49510
dc.identifier.volume44en_US
dc.identifier.wosWOS:000345815400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofMaterials Science & Engineering C-Materials For Biological Applicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThiosemicarbazoneen_US
dc.subjectRutheniumen_US
dc.subjectBiosensoren_US
dc.subjectEnzyme immobilizationen_US
dc.subjectAntimicrobial activityen_US
dc.titleRuthenium (II) complexes of thiosemicarbazone: Synthesis, biosensor applications and evaluation as antimicrobial agentsen_US
dc.typeArticleen_US

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