99mTc-exorphin-glucuronide in tumor diagnosis: Preparation and biodistribution studies in rats

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dc.contributor.authorErtay T.
dc.contributor.authorÜnak P.
dc.contributor.authorÖzdogan O.
dc.contributor.authorBiber F.Z.
dc.contributor.authorZihnioglu F.
dc.contributor.authorMedine E.I.
dc.contributor.authorDurak H.
dc.date.accessioned2019-10-27T08:59:02Z
dc.date.available2019-10-27T08:59:02Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractA glucuronide derivative of exorphin C called exorphin C glucuronide was obtained by enzymatic synthesis and labeled with 99mTc using glucoheptonate (GH) as bifunctional chelating agent. Labeling efficiency was 99.7±0.03%. Biodistribution studies were performed on normal and mammary tumor bearing albino Wistar rats. In addition, scintigraphic imaging with 99mTc-GH-exorphin C glucuronide (99mTc-GEG) was performed. The radiopeptide-glucuronide is rapidly cleared via the urinary system showing lower liver uptake. Results demonstrated that 99mTc-GEG can be used as a vehicle to target tumors. © 2006 Akadémiai Kiadó.en_US
dc.description.sponsorshipParts of the study were presented in 2004 at the 1st International Congress of Radiopharmacy and Radiopharmaceutical Chemistry in Istanbul, Turkey. The authors thank the Ege University Scientific Research Fund for financial support. --en_US
dc.identifier.doi10.1007/s10967-006-0226-2
dc.identifier.endpage28en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-006-0226-2
dc.identifier.urihttps://hdl.handle.net/11454/27655
dc.identifier.volume269en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.title99mTc-exorphin-glucuronide in tumor diagnosis: Preparation and biodistribution studies in ratsen_US
dc.typeArticleen_US

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