99mTc-exorphin-glucuronide in tumor diagnosis: Preparation and biodistribution studies in rats
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A glucuronide derivative of exorphin C called exorphin C glucuronide was obtained by enzymatic synthesis and labeled with 99mTc using glucoheptonate (GH) as bifunctional chelating agent. Labeling efficiency was 99.7±0.03%. Biodistribution studies were performed on normal and mammary tumor bearing albino Wistar rats. In addition, scintigraphic imaging with 99mTc-GH-exorphin C glucuronide (99mTc-GEG) was performed. The radiopeptide-glucuronide is rapidly cleared via the urinary system showing lower liver uptake. Results demonstrated that 99mTc-GEG can be used as a vehicle to target tumors. © 2006 Akadémiai Kiadó.
Açıklama
Anahtar Kelimeler
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
269
Sayı
1
