The role of keto acids in the supportive treatment of children with chronic renal failure

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dc.contributor.authorMir, S
dc.contributor.authorOzkayin, N
dc.contributor.authorAkgun, A
dc.date.accessioned2019-10-27T19:24:50Z
dc.date.available2019-10-27T19:24:50Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractAccording to the hyperfiltration theory of renal diseases characterized by a decrease in the number of functional nephrons, increased arterial blood pressure, excessive protein intake in the diet, high levels of calcium (Ca) and phosphorus (P), secondary hyperparathyroidism, hypertriglyceridemia and/or hypercholesterolemia, proteinuria and metabolic acidosis are some factors that impair the prognosis of the disease. The amount of protein in the diet is the most important of these factors. A protein-restricted diet administered to patients with chronic renal failure results in the risk of inadequate amino acid intake. To overcome this problem, the use of dysaminated alpha-keto analogues has been considered to reduce the risk of nitrogenemia resulting from the continuous intake of essential amino acids. Currently, the necessity of essential amino acids even in adult patients with chronic renal failure is controversial; besides, trials on the use of these amino acids in pediatric patients are scarce. The aim of this study is to investigate the efficacy and applicability of conservative therapy with a protein-restricted diet supplemented with keto acids in the management of chronic renal insufficiency or failure.en_US
dc.identifier.doi10.1007/s00467-005-1860-6en_US
dc.identifier.endpage955en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue7en_US
dc.identifier.pmid15856316en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage950en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-005-1860-6
dc.identifier.urihttps://hdl.handle.net/11454/39305
dc.identifier.volume20en_US
dc.identifier.wosWOS:000229888200019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectketo acidsen_US
dc.subjectchronic renal failureen_US
dc.subjectchildrenen_US
dc.subjectprotein-restricted dieten_US
dc.titleThe role of keto acids in the supportive treatment of children with chronic renal failureen_US
dc.typeArticleen_US

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