Successful treatment of post-transplant Kaposi's sarcoma by reduction of immunosuppression

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dc.contributor.authorDuman, S
dc.contributor.authorToz, H
dc.contributor.authorAsci, G
dc.contributor.authorAlper, S
dc.contributor.authorOzkahya, M
dc.contributor.authorUnal, I
dc.contributor.authorCelik, A
dc.contributor.authorOk, E
dc.contributor.authorBasci, A
dc.date.accessioned2019-10-27T18:17:32Z
dc.date.available2019-10-27T18:17:32Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground. The aim of this study was to investigate retrospectively the clinical presentation, the efficacy of reducing immunosuppression and the consequences of this therapeutic approach in Kaposi's sarcoma (KS) developing after renal transplantation. Methods. We reviewed the records of 502 patients who had been followed up at our transplantation unit between October 1, 1987 and December 30, 1998. Twelve patients (2.4%) with KS were included in the study. Results. The mean age of KS patients was 38+/-11 years (one female, 11 males). All were on prednisone, azathioprine (AZT) and cylcosporin treatment. KS was encountered at a mean of 18+/-0 months post-renal transplantation. Typical Kaposi's lesions were present in the skin of 11 out of 12 patients. In the only patient without skin involvement, who died from haemophagocytic histiocytic syndrome caused by septicaemia, KS was diagnosed post-mortem in a lymph node. In five patients only skin involvement was present, while the others also had visceral involvement (oropharynx in two patients, trachea and lung in three, lymph node in two, stomach and duodenum in two). Cyclosporin was stopped within 1 month after KS diagnosis, and AZT was stopped in three patients. Both cutaneous and visceral KS manifestations disappeared and no patient was lost due to KS. During a follow-up period 46 19 months, KS recurred in the lungs in one patient together with lung tuberculosis, while he was on prednisone and AZT. Two patients lost their graft due to chronic rejection. The remaining eight patients currently have a functioning graft with a mean creatinine level of 1.4+/-0.5 mg/dl. Conclusion. KS is the most frequent post-transplant neoplasia (80%) in our country. In the present study cohort, half of the patients had visceral involvement. Reduction or discontinuation of immunosuppression caused complete remission in all patients without surgical intervention, chemotherapy or radiotherapy.en_US
dc.identifier.doi10.1093/ndt/17.5.892en_US
dc.identifier.endpage896en_US
dc.identifier.issn0931-0509
dc.identifier.issue5en_US
dc.identifier.pmid11981080en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage892en_US
dc.identifier.urihttps://doi.org/10.1093/ndt/17.5.892
dc.identifier.urihttps://hdl.handle.net/11454/35380
dc.identifier.volume17en_US
dc.identifier.wosWOS:000175550800032en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofNephrology Dialysis Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKaposi's sarcomaen_US
dc.subjectkidney transplantationen_US
dc.subjectmalignancyen_US
dc.titleSuccessful treatment of post-transplant Kaposi's sarcoma by reduction of immunosuppressionen_US
dc.typeArticleen_US

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