Multiplexed sensing techniques for cardiovascular disease biomarkers- A review

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dc.authoridMani, Veerappan/0000-0002-0756-7398
dc.authoridDurmus, Ceren/0000-0002-8648-0505
dc.authoridSalama, Khaled Nabil/0000-0001-7742-1282
dc.authorscopusid55286299400
dc.authorscopusid57210729367
dc.authorscopusid57219792887
dc.authorscopusid57216400432
dc.authorscopusid6701638388
dc.authorscopusid8908979300
dc.authorscopusid57203414946
dc.authorwosidMani, Veerappan/J-2696-2014
dc.authorwosidSalama, Khaled Nabil/H-6533-2011
dc.contributor.authorMani, Veerappan
dc.contributor.authorDurmus, Ceren
dc.contributor.authorKhushaim, Walaa
dc.contributor.authorFerreira, Daisy Camargo
dc.contributor.authorTimur, Suna
dc.contributor.authorArduini, Fabiana
dc.contributor.authorSalama, Khaled Nabil
dc.date.accessioned2023-01-12T19:54:29Z
dc.date.available2023-01-12T19:54:29Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractCardiovascular diseases (CVDs) are the number one cause of death worldwide, taking 17.9 million lives each year. The rapid, sensitive, and accurate determination of cardiac biomarkers is vital for the timely diagnosis of CVDs. For accurate diagnosis, dependence on a single biomarker is unreliable because each one has also been linked to other diseases. To overcome this problem, the multiplexed determination of two or more markers has emerged as a promising alternative to single-marker analysis. Over the last 5 years, research interest in the development of biosensors for targeting multiple cardiac markers has increased. In this study, we critically reviewed the various multiplexed biosensing approaches reported during the last 5 years, categorizing them by signal readouts. Prospective detection configurations, capture probes, electrode design strategies, electrode types, nanomaterials, reporter tags, and assay types were reviewed, tabulated, and critically discussed. Then, their advantages and limitations were highlighted. For each category, we provided our perspective as well as the overall critical discussion. Lastly, we summarized potential commercial multiplexed cardiac biosensors and commented on the challenges and future prospects for such sensors.en_US
dc.identifier.doi10.1016/j.bios.2022.114680
dc.identifier.issn0956-5663
dc.identifier.issn1873-4235
dc.identifier.pmid36113389en_US
dc.identifier.scopus2-s2.0-85138120201en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.bios.2022.114680
dc.identifier.urihttps://hdl.handle.net/11454/76437
dc.identifier.volume216en_US
dc.identifier.wosWOS:000859307300003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Advanced Technologyen_US
dc.relation.ispartofBiosensors & Bioelectronicsen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiplexeden_US
dc.subjectSimultaneous detectionen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectMultiple biomarker panelen_US
dc.subjectMyocardial infarctionen_US
dc.subjectImmunoassayen_US
dc.subjectCardiac troponinen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectAcute Myocardial-Infarctionen_US
dc.subjectAcid-Binding Proteinen_US
dc.subjectCardiac Troponin-Ien_US
dc.subjectLateral Flow Assayen_US
dc.subjectEarly-Diagnosisen_US
dc.subjectNatriuretic Peptideen_US
dc.subjectElectrochemical Immunoassayen_US
dc.subjectHuman Serumen_US
dc.subjectMarkersen_US
dc.titleMultiplexed sensing techniques for cardiovascular disease biomarkers- A reviewen_US
dc.typeReviewen_US

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