Transient Tachypnea of the Newborn (TTN): A Role for Polymorphisms of Surfactant Protein B (SP-B) Encoding Gene? [Transiente Tachypnoe des Neugeborenen (TTN): Spielen Polymorphismen im Surfactant-Protein-B-Gen (SP-B) eine Rolle?]

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dc.contributor.authorTutdibi E.
dc.contributor.authorHospes B.
dc.contributor.authorLandmann E.
dc.contributor.authorGortner L.
dc.contributor.authorSatar M.
dc.contributor.authorYurdakök M.
dc.contributor.authorDellagrammaticas H.
dc.contributor.authorÖrs R.
dc.contributor.authorIlikkan B.
dc.contributor.authorOvali F.
dc.contributor.authorSarman G.
dc.contributor.authorKumral A.
dc.contributor.authorArslanoglu S.
dc.contributor.authorKoc H.
dc.contributor.authorYildiran A.
dc.date.accessioned2019-10-27T00:23:23Z
dc.date.available2019-10-27T00:23:23Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Transient tachypnea of the newborn (TTN) is usually a benign self-limiting respiratory disorder in the immediate neonatal period. The lipophilic surfactant-associated protein B (SP-B) was demonstrated to be the most relevant structural component of the surfactant system for immediate postnatal pulmonary adaptation. We hypothesized genetic variations of surfactant protein B (heterozygous 121 ins 2 mutation er intron 4 polymorphisms) to be related to TTN. Patients and Method: We screened genomic DNA of 83 healthy term neonates (gestational age: 39 (37-41) completed weeks [median and range]; birth weight: 3325 ± 541 grams [mean ± SD]) and 75 infants presenting with TTN (gestational age: 38 (37-41) completed wecks [median and range]; birth weight: 3091 ± 435 grams [mean ± SD]) by means of PCR-amplification, fragment length and sequence analysis. TTN was diagnosed an the basis of the clinical signs with respiratory rate > 60 breaths/minute, fraction of inspired oxygen > 0.21, and characteristic radiographic findings within less than 24 hours after birth. Newborns with any infection, pulmonary or cardiac congenital malformations, postnatal asphyxia and infants born to diabetic mothers were excluded. Results: In TTN-group the frequency of male infants (68.4% versus 44.6%, p < 0.05) and caeserian section were significantly higher (68.4% versus 30.1%, p < 0.05). We did not find any statistical difference in frequency of intron 4 variations between controls and TTN-group (8.4% versus 10.7%). None of the infants were heterozygous for the 121ins2 SP-B mutation. Conclusions: WC conclude polymorphisms of intron 4 and heterozygous 121 ins 2 mutation not to associated with TTN.en_US
dc.identifier.doi10.1055/s-2003-42670en_US
dc.identifier.endpage251en_US
dc.identifier.issn0300-8630
dc.identifier.issue5en_US
dc.identifier.pmid14520584en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage248en_US
dc.identifier.urihttps://doi.org/10.1055/s-2003-42670
dc.identifier.urihttps://hdl.handle.net/11454/22804
dc.identifier.volume215en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isodeen_US
dc.relation.ispartofKlinische Padiatrieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRespiratory failureen_US
dc.subjectSP-B polymorphismsen_US
dc.subjectTransient tachypnea of the newbornen_US
dc.titleTransient Tachypnea of the Newborn (TTN): A Role for Polymorphisms of Surfactant Protein B (SP-B) Encoding Gene? [Transiente Tachypnoe des Neugeborenen (TTN): Spielen Polymorphismen im Surfactant-Protein-B-Gen (SP-B) eine Rolle?]en_US
dc.typeArticleen_US

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