Clinical value of a set of neuropeptides in term and preterm neonates with seizures: Brain derived neurotrophic factor, galanin and neuropeptide Y

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dc.contributor.authorTanriverdi, Mahir
dc.contributor.authorKultursay, Nilgun
dc.contributor.authorTekgul, Hasan
dc.contributor.authorSozmen, Eser
dc.contributor.authorKoroglu, Ozge Altun
dc.contributor.authorAktan, Gul
dc.contributor.authorYalaz, Mehmet
dc.date.accessioned2020-12-01T12:01:46Z
dc.date.available2020-12-01T12:01:46Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of our study to investigate clinical value of a set of neuropeptides (brain derived neurotrophic factor-BDNF, galanin and neuropeptide Y-NPY) in critically ill neonates. A total of 53 neonates (preterm: 26, term: 27) evaluated with lumbar pucture for etiologic evaluation were consequtively included into the study. Serum and CSF levels of the neuropeptides were measured in the first 48 h of life. All infants were prospectively followed for prognostic outcome (survival and neurodevelopmental) at the first year of life. the study cohort was categorized into four groups with respect to seizure development; preterm neonates with or without seizure and term neonates with or without seizure. Mean CSF levels of NPY (pg/ml) were significantly higher in term neonates with than those without seizures (389.76 vs. 122.66) and galanin (3.31 vs. 1.55) respectively. Term neonates with seizures had significantly higher serum levels of NPY (ng/mL) as compared with neonates without seizures (54.00 vs. 9.10). No significant difference was noted in serum and CSF levels for the set of neuropeptides in neonates with respect to prognostic outcome. Serum NPY and CSF NPY and galanin levels have a potential role for detection of clinical seizures in term neonates. (C) 2020 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipResearch Committee of Ege University Medical Faculty [2012MED-018]en_US
dc.description.sponsorshipThis study was financially supported by the Research Committee of Ege University Medical Faculty (Project Number: 2012MED-018).en_US
dc.identifier.doi10.1016/j.jocn.2020.02.013en_US
dc.identifier.endpage174en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.pmid32098713en_US
dc.identifier.scopus2-s2.0-85080091775en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage168en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2020.02.013
dc.identifier.urihttps://hdl.handle.net/11454/62519
dc.identifier.volume74en_US
dc.identifier.wosWOS:000527311400032en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuropeptidesen_US
dc.subjectBDNFen_US
dc.subjectGalaninen_US
dc.subjectneuropeptide Yen_US
dc.subjectNeonatal seizuresen_US
dc.subjectOutcomeen_US
dc.titleClinical value of a set of neuropeptides in term and preterm neonates with seizures: Brain derived neurotrophic factor, galanin and neuropeptide Yen_US
dc.typeArticleen_US

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