Effects of inherited trombophilia in women with recurrent pregnancy loss

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dc.contributor.authorHabibovic, Z.
dc.contributor.authorZeybek, B.
dc.contributor.authorSanhal, C.
dc.contributor.authorEroglu, Z.
dc.contributor.authorKaraca, E.
dc.contributor.authorUlukus, M.
dc.date.accessioned2019-10-27T21:26:50Z
dc.date.available2019-10-27T21:26:50Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose of Investigation: To evaluate the prevalence and effects of inherited thrombophilia caused by factor V Leiden, prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations in women with recurrent pregnancy loss. Methods: A study group of 97 women with recurrent miscarriages and a control group of 71 healthy pregnant women were included in the study. Genotype analyses for factor V Leiden, prothrombin G20210A and MTHFR C677T polymorphisms were performed by real-time polymerase chain reaction (RT-PCR). Results: The frequency of factor V Leiden, prothrombin G20210A and MTHFR C677T mutations were similar in both the study and control group. There were eight patients (8.2%) who had more than one gene mutation in the study group and one patient in the control group (1.4%). This difference was not statistically significant. Study group patients (n = 97) were compared in terms of the number of miscarriages and the abortion week, in addition to being a carrier of factor V Leiden and MTHFR C677T gene mutations. No statistically significant correlation was found between being a factor V Leiden and MTHFR C677T mutation carrier with either the number of miscarriages or the abortion week. Conclusion: Factor V Leiden, prothrombin G20210A and MTHFR C677T gene mutations are not individually related with recurrent pregnancy loss. However, combined gene mutation status may be associated with recurrent miscarriages.en_US
dc.identifier.endpage350en_US
dc.identifier.issn0390-6663
dc.identifier.issue4en_US
dc.identifier.pmid22268272en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage347en_US
dc.identifier.urihttps://hdl.handle.net/11454/45010
dc.identifier.volume38en_US
dc.identifier.wosWOS:000297948600013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRecurrent pregnancy lossen_US
dc.subjectFactor V Leidenen_US
dc.subjectProthrombinen_US
dc.subjectMTHFRen_US
dc.titleEffects of inherited trombophilia in women with recurrent pregnancy lossen_US
dc.typeArticleen_US

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