Does matrix metalloproteinase activity predict severity of acute pancreatitis?

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dc.contributor.authorAynaci, Murat
dc.contributor.authorTuncyurek, Pars
dc.contributor.authorNart, Deniz
dc.contributor.authorZeytunlu, Murat
dc.contributor.authorOzutemiz, Omer
dc.contributor.authorErsoz, Galip
dc.contributor.authorYilmaz, Funda
dc.contributor.authorMayer, Jens
dc.contributor.authorCoker, Ahmet
dc.date.accessioned2019-10-27T19:17:21Z
dc.date.available2019-10-27T19:17:21Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Matrix metalloproteinases (MMP) modulate end-organ complications of acute pancreatitis, but the correlation between increased MMP production and histological severity of disease remains unclear. We examined the role of MMD and pancreas histology on experimental acute pancreatitis. Methods: Forty male Wistar albino rats were subjected to cerulein-induced pancreatitis (8, 16, 24 and 32 h groups) or sham treatment. The animals were killed at different time points and pancreatic tissues were harvested to assess MMP (1, 2 and 9) activity and inflammatory changes. Results: Compared with other groups, 8 h group had decreased tissue MMP-1 concentrations. MMP-9 concentrations were lower in 24-h and 32-h groups, as were histological severity scores. MMP-2 activity did not differ among groups. Pancreatitis was prominent in 8-h, 16-h and 24-h groups by means of histology. Conclusion: Induction of pancreatitis by cerulein altered pancreatic MMP levels in the early phase of inflammation. Inhibition of MMP-2 and MMP-9 paralleled histological scores. Therefore, MMP may have a predictive value to assess histological severity.en_US
dc.identifier.doi10.1111/j.1445-2197.2006.03871.xen_US
dc.identifier.endpage804en_US
dc.identifier.issn1445-1433
dc.identifier.issue9en_US
dc.identifier.pmid16922902en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage801en_US
dc.identifier.urihttps://doi.org/10.1111/j.1445-2197.2006.03871.x
dc.identifier.urihttps://hdl.handle.net/11454/38360
dc.identifier.volume76en_US
dc.identifier.wosWOS:000240336800010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofAnz Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmatrix metalloproteinaseen_US
dc.subjectpancreatic injuryen_US
dc.subjectpancreatitisen_US
dc.titleDoes matrix metalloproteinase activity predict severity of acute pancreatitis?en_US
dc.typeArticleen_US

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