The Risk Factors of Puberty Precocious in Girls: Is the Condition Related with Polychlorobiphenyls?

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dc.authoridOzen, Samim/0000-0001-7037-2713
dc.authorwosidOzen, Samim/A-4342-2016
dc.contributor.authorBilgin, Raziye Burcu Guven
dc.contributor.authorOzen, Samim
dc.contributor.authorGoksen, Ruhsar Damla
dc.contributor.authorKorkmaz, Ozlem
dc.contributor.authorDarcan, Sukran
dc.date.accessioned2023-01-12T20:16:43Z
dc.date.available2023-01-12T20:16:43Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractAim: Our aim was investigate the effect of polychlorobifenyls (PCBs) and other factors on puberty precocious (PP) in girls were diagnosed with idiopatic PP and premature thelarche (PT). Materials and Methods: The study group included 50 girls aged between 2-8 years old with PP and PT. The control group included 50 healthy girls with same age range and no puberty findings. Data was collected in terms of breast and pubic hair stages, weight, height, body mass index (BMI), standard deviation scores (SDSs), location of residence, gestational age and maternal age at menarche (AAM). Twenty-one PCB levels were evaluated in serum and urine. One-Way ANOVA test was used for comparison between the groups. For subgroup analysis, Mann-Whitney U test, multiple regression analysis were used. Results: The mean age of the study and control groups were 6.70 +/- 1.20 and 5.23 +/- 1.25 years, respectively. The studied PCBs were not detectable found in either the study or the control groups. The BMI SDSs of the patients in study and healthy groups were 0.49 +/- 1.09 and-0.12 +/- 1.28, respectively (p=0.1). Weight SDSs in the study group were found to be significantly higher than healthy group (0.72 +/- 1.35 vs-0.20 +/- 1.47, p=0.008 Maternal AAM of the patients in study group was significantly lower (p=0.006). In study group 98% of the patients were living in down town and district, whereas this ratio was 92% in control group (p=0.024). In study group 29 patients (58%) were diagnosed with PT. Basal follicle stimulating hormone and estradiol levels, bone age and uterine longest axis dimensions results were significantly different. Conclusion: We found that studied PCBs don't influence on PP in girls aged between 2-8 years old. However, weight SDS, maternal AAM, location of residence of the patients had a significant role on PP in this patient population.en_US
dc.identifier.doi10.4274/jpr.galenos.2021.67689
dc.identifier.endpage413en_US
dc.identifier.issn2147-9445
dc.identifier.issue4en_US
dc.identifier.startpage408en_US
dc.identifier.trdizinid482495en_US
dc.identifier.urihttps://doi.org/10.4274/jpr.galenos.2021.67689
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/482495
dc.identifier.urihttps://hdl.handle.net/11454/78763
dc.identifier.volume8en_US
dc.identifier.wosWOS:000718894700008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal Of Pediatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPuberty precociousen_US
dc.subjectpremature thelarcheen_US
dc.subjectenvironmental endocrine distrubsen_US
dc.subjectpolychlorobifenylen_US
dc.subjectobesityen_US
dc.subjectIn-Utero Exposureen_US
dc.subjectPolychlorinated-Biphenylsen_US
dc.subjectReproductive Functionen_US
dc.subjectSecular Trendsen_US
dc.subjectAgeen_US
dc.subjectPesticidesen_US
dc.subjectEndocrineen_US
dc.subjectMenarcheen_US
dc.subjectBreasten_US
dc.subjectOnseten_US
dc.titleThe Risk Factors of Puberty Precocious in Girls: Is the Condition Related with Polychlorobiphenyls?en_US
dc.typeArticleen_US

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