The effects of Levothyroxine on the structure and dynamics of DPPC liposome: FTIR and DSC studies
Küçük Resim Yok
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Levothyroxine (3,5,3',5'-tetraiodothyronine), which is a L-isomer of thyroxine T4 (L-T4), is a synthetic thyroid hormone that is biochemically and physiologically indistinguishable from endogenous T4. It is used as a thyroid hormone replacement drug to treat an underactive thyroid gland. the interaction of L-T4, with zwitterionic dipalmitoyl phosphatidylcholine (DPPC) multilamellar liposomes (MLVs) was studied in the presence (1 mol%, 3 mol%, 6 mol%, 9 mol%, 15 mol%, 24 mol% and 30 mol%) and absence of L-T4 by using two different non-invasive techniques; Fourier Transform Infrared (FTIR) spectroscopy and Differential Scanning Calorimetry (DSC). the results show that L-T4 does perturb the phase transition profile by either decreasing the main transition temperature (T-m) and enthalpy (Delta H) or increasing the width at half height (Delta T-1/2). That means; it changes the physical properties of DPPC bilayers. Addition of L-T4 into pure DPPC liposomes shifts the phase transition to lower temperature, disorder the system in gel phase with opposite effect in liquid-crystalline phase and increases the dynamics of the system in both phases and also causes dehydration of the groups of lipids and the water molecules around.
Açıklama
Anahtar Kelimeler
Levothyroxine, Dipalmitoyl phosphatidylcholine, Drug-membrane interaction, Fourier transform infrared, Differential scanning calorimetry
Kaynak
Biochimica Et Biophysica Acta-Biomembranes
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
1862
Sayı
6
