In vitro activities of various antimicrobials against Brucella melitensis strains in the Aegean Region in Turkey

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dc.contributor.authorYamazhan T.
dc.contributor.authorAydemir Ş.
dc.contributor.authorTünger A.
dc.contributor.authorSerter D.
dc.contributor.authorGökengin D.
dc.date.accessioned2019-10-27T00:10:18Z
dc.date.available2019-10-27T00:10:18Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To study in vitro activities of three quinolones (ciprofloxacin, levofloxacin, moxifloxacin), four macrolides (erythromycin, dirithromycin, azithromycin, clarithromycin) and doxycycline against 44 clinical isolates of Brucella melitensis. Materials and Methods: Forty-four B. melitensis strains were isolated from blood cultures of adult patients with acute brucellosis who were hospitalized in the clinical ward of the Department of Clinical Microbiology and Infectious Diseases. The minimum inhibitory concentrations (MICs) of the tested antimicrobials were measured by the agar dilution method. MIC90 and MIC50 values were defined as the lowest concentration of the antibiotic at which 90 and 50% of the isolates were inhibited, respectively. Results: Doxycycline (MIC50: 0.25 µg/ml, MIC90: 0.50 µg/ml) had the low-est MIC in vitro against the B. melitensis strains. Among the quinolones, ciprofloxacin and levofloxacin had similar activities (MIC50: 0.5 µg/ml, MIC90: 2 µg/ml), whereas MIC of moxifloxacin (MIC50:1 µg/ml, MIC 90: 8 µg/ml) was higher than both antibiotics in this group. Clarithromycin and azithromycin were the most active macrolides (MIC 50: 8 µg/ml and MIC90: 32 µg/ml), followed by erythromycin (MIC50: 16 µg/ml, MIC90: 32 µg/ml) and dirithromycin (MIC50: 64 µg/ml and MIC90: 64 µg/ml). Conclusion: The results indicate that the conventional agent doxycycline is more active than quinolones and macrolides against the B. melitensis in vitro. Copyright © 2005 S. Karger AG.en_US
dc.identifier.doi10.1159/000088122en_US
dc.identifier.endpage416en_US
dc.identifier.issn1011-7571
dc.identifier.issue6en_US
dc.identifier.pmid16220015en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage413en_US
dc.identifier.urihttps://doi.org/10.1159/000088122
dc.identifier.urihttps://hdl.handle.net/11454/21930
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofMedical Principles and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgar dilution methoden_US
dc.subjectAntibiotic susceptibilityen_US
dc.subjectBrucella melitensisen_US
dc.titleIn vitro activities of various antimicrobials against Brucella melitensis strains in the Aegean Region in Turkeyen_US
dc.typeArticleen_US

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