The Effect of Hormone Replacement Treatment on Thrombin-Activatable Fibrinolysis Inhibitor Activity Levels in Patients with Hashimoto Thyroiditis

Basit Öğe Kaydı
dc.contributor.authorCetinkalp, Sevki
dc.contributor.authorTobu, Mahmut
dc.contributor.authorKaradeniz, Muammer
dc.contributor.authorBuyukkececi, Filiz
dc.contributor.authorYilmaz, Candeger
dc.date.accessioned2019-10-27T20:20:33Z
dc.date.available2019-10-27T20:20:33Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Hypothyroid patients have increased risk of cardiovascular diseases, and several mechanisms have been considered responsible in these patients. Although, a few studies demonstrated fibrinolytic system changes in hypothyroid patients, there is no study demonstrating TAFI activity in hypothyroid Hashimoto's thyroiditis patients. The aim of this study was to evaluate TAFI activity status and the effect of L thyroxin hormone replacement treatment on fibrinolytic system in this patient group. Methods Thirty patients with hypothyroid Hashimoto thyroiditis (all were female and the mean age was 44.3 +/- 14.6 years, ranging between 17-68 years) were enrolled to study. Their TSH levels were high (27.2 +/- 5.2 mU/L) and Free T3 and Free T4 hormone levels were below than normal. In this study, euthyroid 20 healthy volunteers (mean age 32.5 +/- 4.9 years, range 26-42 years) were adopted. L-thyroxin treatment before and after TAFI activity levels were measured in patients. Results In the control group, TAFI activity levels were 9.6 +/- 0.4 mu g/mL. In patients with L-thyroxin before and after treatment there were high levels of TAFI activity value of 14.2 +/- 0.9 and 12.9 +/- 0.8 mu g/mL, respectively. In the patient group, after L-thyroxin treatment TAFI activity levels were decreased but they were not statistically significant (p=0.187). When compared to the control group, high levels of TAFI activity were observed in the patient group (p<0.0001). Conclusion Our data demonstrated that in Hashimoto thyroiditis, patients have high levels of TAFI activity compared to controls. A high level of TAFI activity suggests fibrinolytic deficit or thrombotic tendency in hypothyroid patients and this deficit is persistent after L-thyroxine replacement.en_US
dc.identifier.doi10.2169/internalmedicine.48.1758en_US
dc.identifier.endpage285en_US
dc.identifier.issn0918-2918
dc.identifier.issn1349-7235
dc.identifier.issue5en_US
dc.identifier.pmid19252348en_US
dc.identifier.startpage281en_US
dc.identifier.urihttps://doi.org/10.2169/internalmedicine.48.1758
dc.identifier.urihttps://hdl.handle.net/11454/41643
dc.identifier.volume48en_US
dc.identifier.wosWOS:000264042100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapan Soc Internal Medicineen_US
dc.relation.ispartofInternal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHashimoto's thyroiditisen_US
dc.subjectthrombin-activatable fibrinolysis inhibitor activityen_US
dc.titleThe Effect of Hormone Replacement Treatment on Thrombin-Activatable Fibrinolysis Inhibitor Activity Levels in Patients with Hashimoto Thyroiditisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu