Fabrication of Thymoquinone-Loaded Albumin Nanoparticles by Microfluidic Particle Synthesis and Their Effect on Planarian Regeneration

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dc.contributor.authorKazan, Aslihan
dc.contributor.authorYesil-Celiktas, Ozlem
dc.contributor.authorZhang, Yu Shrike
dc.date.accessioned2020-12-01T12:09:06Z
dc.date.available2020-12-01T12:09:06Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.descriptionZhang, Yu Shrike/0000-0002-0045-0808; Kazan, Aslihan/0000-0002-8947-8494en_US
dc.description.abstractThymoquinone is the main bioactive component of the plant Nigella sativa, which is commonly known as black seeds and has several therapeutic effects. However, clinical applications of thymoquinone are limited due to its hydrophobic nature. in this study, thymoquinone is encapsulated in albumin nanoparticles by using a microfluidic platform to overcome this limitation. the mean particle sizes of empty and thymoquinone-loaded nanoparticles are determined as 271.3 and 315.6 nm, respectively, with polydispersity index values both lower than 0.25. in addition to particle size distribution measurements, characterizations of the prepared nanoparticles such as zeta potential measurements, in vitro release studies, as well as scanning electron microscopy, Fourier-transform infrared, and differential scanning calorimetry analyses are also carried out. To determine the effect of thymoquinone on neural regeneration, planarians are used as the model organism. After application of free and encapsulated thymoquinone, planarians are amputated and the fragments are observed in terms of head and tail regeneration, swimming pattern, and behavior. the results indicate that thymoquinone affects their behavior and primarily enhances head regeneration of planarians. in addition, it is shown that encapsulation of thymoquinone not only enhances the thermal stability of the molecule but also decreases its toxicity.en_US
dc.identifier.doi10.1002/mabi.201900182en_US
dc.identifier.issn1616-5187
dc.identifier.issn1616-5195
dc.identifier.issue11en_US
dc.identifier.pmid31609099en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/mabi.201900182
dc.identifier.urihttps://hdl.handle.net/11454/63302
dc.identifier.volume19en_US
dc.identifier.wosWOS:000492464900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofMacromolecular Bioscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalbumin nanoparticlesen_US
dc.subjectmicrofluidicsen_US
dc.subjectplanariansen_US
dc.subjectregenerationen_US
dc.subjectthymoquinoneen_US
dc.titleFabrication of Thymoquinone-Loaded Albumin Nanoparticles by Microfluidic Particle Synthesis and Their Effect on Planarian Regenerationen_US
dc.typeArticleen_US

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