Relaxation mechanisms of chloroform root extracts of Prangos heyniae and Prangos uechtritzii on mouse corpus cavernosum

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dc.authoridAlbayrak, Gokay/0000-0002-5729-0796
dc.authoridSevin, Gulnur/0000-0003-4814-9245
dc.authoridYetik Anacak, Gunay/0000-0002-7788-1657
dc.authoridAlan, Elif/0000-0001-9636-4068
dc.authorscopusid57329388100
dc.authorscopusid57197819294
dc.authorscopusid8970943500
dc.authorscopusid14032536900
dc.authorscopusid23767071300
dc.authorwosidYetik Anacak, Gunay/A-1418-2018
dc.contributor.authorAlan, Elif
dc.contributor.authorAlbayrak, Gokay
dc.contributor.authorSevin, Gulnur
dc.contributor.authorYetik-Anacak, Gunay
dc.contributor.authorBaykan, Sura
dc.date.accessioned2023-01-12T20:01:43Z
dc.date.available2023-01-12T20:01:43Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractErectile dysfunction (ED) is the inability to achieve/maintain an erection. Because of the side effects, interactions, or ineffectiveness of currently used drugs, novel drug discovery studies are ongoing. The roots of Turkish endemic plants Prangos uechtritzii and Prangos heyniae are traditionally used as aphrodisiacs in Anatolia and contain coumarin-like relaxant compounds. This study aims to reveal the relaxant effect mechanisms of chloroform root extracts of P. heyniae (Ph-CE) and P. uechtritzii (Pu-CE). Isolated organ bath experiments were performed on Swiss albino mouse corpus cavernosum by DMT strip myograph. Relaxant responses to extract (10(-7)-10(-4) g/ml) were obtained in the presence/absence of NO and H2S synthesis inhibitors nitro-l-arginine methyl ester (l-NAME, 100 mu M) and aminooxyacetic acid (AOAA, 10 mM) respectively. Sodium nitroprusside (SNP, 10(-9) to 10(-4) M) and Na2S (10(-6) to 3 x 10(-3) M)-induced relaxations and CaCl2 (10(-6) to 10(-4) M), KCl (10(-2.1) to 10(-0.9) M) and phenylephrine (3 x 10(-8) to 3 x 10(-5) M)-induced contractions were taken in the presence/absence of the extracts (10(-4) g/ml). Relaxations induced by Ph-CE but not by Pu-CE were inhibited in the presence of l-NAME and AOAA. Ph-CE increased Na2S- and SNP-induced relaxations. Ph-CE and Pu-CE decreased the contractions of KCl, phenylephrine, and CaCl2. It was concluded that NO and H2S synthesis/downstream mechanisms play roles in relaxations of Ph-CE but not in Pu-CE-induced relaxations. Inhibition of calcium influx appears to be involved in the relaxant effect of Ph-CE and Pu-CE. Since the extracts act directly by relaxing smooth muscle or through H2S as well as NO, they may be a potential therapeutic agent in diseases such as ED where the bioavailability of NO is impaired.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu [117-S-116]en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Number: 117-S-116en_US
dc.identifier.doi10.1111/and.14604
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.pmid36163644en_US
dc.identifier.scopus2-s2.0-85139056084en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.14604
dc.identifier.urihttps://hdl.handle.net/11454/77510
dc.identifier.wosWOS:000860950100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcalcium channelsen_US
dc.subjectcorpus cavernosumen_US
dc.subjecthydrogen sulphideen_US
dc.subjectnitric oxideen_US
dc.subjectPrangosen_US
dc.subjectErectile Dysfunctionen_US
dc.subjectHydrogen-Sulfideen_US
dc.subjectCalcium-Channelen_US
dc.subjectNitric-Oxideen_US
dc.subjectOstholeen_US
dc.subjectVasodilatationen_US
dc.subjectImperatorinen_US
dc.subjectMediatoren_US
dc.titleRelaxation mechanisms of chloroform root extracts of Prangos heyniae and Prangos uechtritzii on mouse corpus cavernosumen_US
dc.typeArticleen_US

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