Association Between Pancreatic Intraductal Papillary Mucinous Neoplasms and Extrapancreatic Malignancies

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dc.contributor.authorMarchegiani, Giovanni
dc.contributor.authorMalleo, Giuseppe
dc.contributor.authorD'Haese, Jan G.
dc.contributor.authorWenzel, Patrick
dc.contributor.authorKeskin, Muharrem
dc.contributor.authorPugliese, Luigi
dc.contributor.authorBorin, Alex
dc.contributor.authorBenning, Valentina
dc.contributor.authorNilsson, Linda
dc.contributor.authorOruc, Nevin
dc.contributor.authorSegersvard, Ralf
dc.contributor.authorFriess, Helmut
dc.contributor.authorSchmid, Roland
dc.contributor.authorLohr, Matthias
dc.contributor.authorMaisonneuve, Patrick
dc.contributor.authorBassi, Claudio
dc.contributor.authorCeyhan, Gueralp O.
dc.contributor.authorSalvia, Roberto
dc.contributor.authorDel Chiaro, Marco
dc.date.accessioned2019-10-27T20:25:02Z
dc.date.available2019-10-27T20:25:02Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractBACKGROUND & AIMS: The association between pancreatic intraductal papillary mucinous neoplasms (IPMNs) and extrapancreatic neoplasms (EPNs) is controversial. We performed a multicenter observational study to assess the incidence of EPNs after an IPMN diagnosis. METHODS: 1340 patients with IPMNs were evaluated from 2000 through 2013 at 4 academic institutions in Europe for development of EPN. To estimate the actual incidence of EPN, we excluded patients with an EPN previous or synchronous to the IPMN, and patients who had been followed for less than 12 months, resulting in a study population of 816 patients. The incidence of EPN was compared with sex-specific, age-adjusted European cancer statistics; the standardized incidence ratio (SIR), and the 5- and 10-year cumulative incidence rates were calculated. RESULTS: A total of 290/1340 patients had a history of EPN (prevalence of 21.6%). In this subgroup of patients, the IPMN was discovered incidentally in 241. Among the 816 patients included in the incidence analysis, 50 developed an EPN after a median time of 46 months from study enrollment. The incidence of any EPN was not greater in patients with than without IPMN with a SIR of 1.48 (95% confidence interval, 0.94-2.22) in males and of 1.39 (95% CI 0.90-2.05) in females. The 5-and 10-year cumulative incidence rates for development of EPN in patients with IPMN were 7.9% and 16.6% in men, and 3.4% and 23.1% in women. CONCLUSIONS: Patients with IPMN do not have a significantly higher incidence of EPNs than the general European population. It might not be necessary to screen patients with IPMN for EPN.en_US
dc.identifier.doi10.1016/j.cgh.2014.11.029en_US
dc.identifier.endpage1169en_US
dc.identifier.issn1542-3565
dc.identifier.issn1542-7714
dc.identifier.issue6en_US
dc.identifier.pmid25478920en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1162en_US
dc.identifier.urihttps://doi.org/10.1016/j.cgh.2014.11.029
dc.identifier.urihttps://hdl.handle.net/11454/42193
dc.identifier.volume13en_US
dc.identifier.wosWOS:000354824000028en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofClinical Gastroenterology and Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCystic Lesion of the Pancreasen_US
dc.subjectCanceren_US
dc.subjectExtrapancreatic Tumorsen_US
dc.subjectFollow Upen_US
dc.titleAssociation Between Pancreatic Intraductal Papillary Mucinous Neoplasms and Extrapancreatic Malignanciesen_US
dc.typeArticleen_US

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