Urinary glycosaminoglycan concentrations in postmenopausal osteoporosis
Küçük Resim Yok
Tarih
1997
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
the organic bone matrix contains glycosaminoglycans (GAGs). Structural changes in bones with inflammatory and degenerative processes generally lead to the break-down of macromolecules from connective tissue and increase their urinary excretion. in the present study, the levels of urinary GAGs were investigated in 28 healthy controls consisting of 18 premenopausal and 10 postmenopausal women and 25 patients with postmenopausal and 10 postmenopausal women and in 25 patients with postmenopausal osteoporosis. Urinary GAGs were measured in 24 hour collected urine samples by the carbazole method and corrected for the excretion level of creatinine. There was a significant increase in GAGs excretion in patients with postmenopausal osteoporosis compared with healthy premenopausal (p<0.01) and healty postmenopausal subjects (p<0.01). (4.57+-0.69 in healty premenopausal and 5.34+-1.64 mm/mol creatinine in healty postmenopausal vs 12.31+-1.01 mmol/mol creatinine in postmnopausal osteoporotic women). Bone mineral density was measured by dual photon absortiometer. Bone mineral density was determined to be significantly lower in postmenopausal women with osteoporosis in comparison to the control group (p<0.05). in urine samples collected in the 4. week of salmon calcitonin (SCT) treatment (100 IU/d Miacalsic), GAG excretion decreased significantly in the osteoporotic women, suggesting that this urinary parameter might be useful in monitoring alterations in bone metabolism.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
27
Sayı
3
