Achievement of low-density lipoprotein cholesterol goals in 18 countries outside Western Europe: The International ChoLesterol management Practice Study (ICLPS)

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dc.contributor.authorDanchin, Nicolas
dc.contributor.authorAlmahmeed, Wael
dc.contributor.authorAl-Rasadi, Khalid
dc.contributor.authorAzuri, Joseph
dc.contributor.authorBerrah, Abdelkrim
dc.contributor.authorCuneo, Carlos Alberto
dc.contributor.authorKarpov, Yuri
dc.contributor.authorKaul, Upendra
dc.contributor.authorKayikcioglu, Meral
dc.contributor.authorMitchenko, Olena
dc.contributor.authorRuiz, Alvaro J.
dc.contributor.authorSalinas, Carlos A. Aguilar
dc.contributor.authorSantos, Raul D.
dc.contributor.authorMercier, Florence
dc.contributor.authorBlom, Dirk
dc.date.accessioned2019-10-27T10:04:12Z
dc.date.available2019-10-27T10:04:12Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Little is known about the achievement of low density lipoprotein cholesterol (LDL-C) targets in patients at cardiovascular risk receiving stable lipid-lowering therapy (LLT) in countries outside Western Europe. Methods This cross-sectional observational study was conducted in 452 centres (August 2015-August 2016) in 18 countries in Eastern Europe, Asia, Africa, the Middle East and Latin America. Patients (n=9049) treated for 3 months with any LLT and in whom an LDL-C measurement on stable LLT was available within the previous 12 months were included. Results The meanSD age was 60.2 +/- 11.7 years, 55.0% of patients were men and the mean +/- SD LDL-C value on LLT was 2.6 +/- 1.3mmol/L (101.0 +/- 49.2mg/dL). At enrolment, 97.9% of patients were receiving a statin (25.3% on high intensity treatment). Only 32.1% of the very high risk patients versus 51.9% of the high risk and 55.7% of the moderate risk patients achieved their LDL-C goals. On multivariable analysis, factors independently associated with not achieving LDL-C goals were no (versus lower dose) statin therapy, a higher (versus lower) dose of statin, statin intolerance, overweight and obesity, female sex, neurocognitive disorders, level of cardiovascular risk, LDL-C value unknown at diagnosis, high blood pressure and current smoking. Diabetes was associated with a lower risk of not achieving LDL-C goals. Conclusions These observational data suggest that the achievement of LDL-C goals is suboptimal in selected countries outside Western Europe. Efforts are needed to improve the management of patients using combination therapy and/or more intensive LLTs.en_US
dc.description.sponsorshipSanofiSanofi-Aventisen_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: sponsored by Sanofi.en_US
dc.identifier.doi10.1177/2047487318777079en_US
dc.identifier.endpage1094en_US
dc.identifier.issn2047-4873
dc.identifier.issn2047-4881
dc.identifier.issue10en_US
dc.identifier.pmid29771156en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1087en_US
dc.identifier.urihttps://doi.org/10.1177/2047487318777079
dc.identifier.urihttps://hdl.handle.net/11454/30212
dc.identifier.volume25en_US
dc.identifier.wosWOS:000438569100017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofEuropean Journal of Preventive Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCholesterolen_US
dc.subjectstatinsen_US
dc.subjectlipidsen_US
dc.subjectobservational studyen_US
dc.subjectguidelinesen_US
dc.titleAchievement of low-density lipoprotein cholesterol goals in 18 countries outside Western Europe: The International ChoLesterol management Practice Study (ICLPS)en_US
dc.typeArticleen_US

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