Association between resistin level and renal function in patients undergoing coronary artery bypass graft surgery

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dc.contributor.authorGungor H.
dc.contributor.authorKirilmaz B.
dc.contributor.authorZorlu A.
dc.contributor.authorOguz E.
dc.contributor.authorFatih Ayik M.
dc.contributor.authorKumak F.
dc.contributor.authorZoghi M.
dc.date.accessioned2019-10-26T21:55:57Z
dc.date.available2019-10-26T21:55:57Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: The purpose of this study was to evaluate the association between resistin levels and renal function in patients undergoing coronary artery bypass graft (CABG) surgery. Methods: Thirty-seven consecutive patients (mean T SD, age 60 T 10 years, 29 (78%) male) undergoing CABG surgery at our department were enrolled into our study. Blood samples were taken to examine quantities of resistin level and other blood parameters the day before surgery. The patients were categorized into 2 groups: lower resistin level (group 1) or higher resistin level (group 2) according to the median value of 9 ng/mL. Results: Mean T SD resistin level, glomerular filtration rate (GFR), and urea and creatinine levels were 9.5 T 4.2 ng/mL, 78 T 25 mL/min per 1.73 m2, 42 T 14 mg/dL, and 1.08 T 0.2 mg/dL, respectively. Resistin showed significant correlation with serum levels of urea (r = 0.448l P = 0.005), creatinine (r = 0.367; P = 0.026), inverse correlation with GFR (r =j0.398; P = 0.015), statin usage (r =j0.393; P = 0.016), and A-blocker usage (r = j0.365; P = 0.026). In the multivariate logistic regression model, only GFR (odds ratio, 0.960; 95 confidence interval, 0.928-0.993; P = 0.018) remained independently associated with higher resistin levels after adjustment of other potential confounders in patients undergoing CABG surgery. According to the receiver operating characteristics curve analysis, the optimal cutoff value of GFR to predict higher resistin levels was found as 91 mL/min or less per 1.73 m2, with 100% sensitivity and 61.1% specificity. Conclusion: The present study demonstrated that a lower glomerular filtration rate was associated with higher circulating resistin levels, independent of coronary heart disease risk factors in patients undergoing CABG surgery. Copyright © 2012 by The American Federation for Medical Research.en_US
dc.identifier.doi10.2310/JIM.0b013e31825459f9en_US
dc.identifier.endpage887en_US
dc.identifier.issn1708-8267
dc.identifier.issue6en_US
dc.identifier.pmid22534631en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage883en_US
dc.identifier.urihttps://doi.org/10.2310/JIM.0b013e31825459f9
dc.identifier.urihttps://hdl.handle.net/11454/19006
dc.identifier.volume60en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.ispartofJournal of Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary artery bypass graft surgeryen_US
dc.subjectRenal functionen_US
dc.subjectResistinen_US
dc.titleAssociation between resistin level and renal function in patients undergoing coronary artery bypass graft surgeryen_US
dc.typeArticleen_US

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