Portraying infective endocarditis: results of multinational ID-IRI study

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dc.contributor.authorErdem, Hakan
dc.contributor.authorPuca, Edmond
dc.contributor.authorRuch, Yvon
dc.contributor.authorSantos, Lurdes
dc.contributor.authorGhanem-Zoubi, Nesrin
dc.contributor.authorArgemi, Xavier
dc.contributor.authorHansmann, Yves
dc.contributor.authorGuner, Rahmet
dc.contributor.authorTonziello, Gilda
dc.contributor.authorMazzucotelli, Jean-Philippe
dc.contributor.authorComo, Najada
dc.contributor.authorKose, Sukran
dc.contributor.authorBatirel, Ayse
dc.contributor.authorInan, Asuman
dc.contributor.authorTulek, Necla
dc.contributor.authorPekok, Abdullah Umut
dc.contributor.authorKhan, Ejaz Ahmed
dc.contributor.authorIyisoy, Atilla
dc.contributor.authorMeric-Koc, Meliha
dc.contributor.authorKaya-Kalem, Ayse
dc.contributor.authorMartins, Pedro Palma
dc.contributor.authorHasanoglu, Imran
dc.contributor.authorSilva-Pinto, Andre
dc.contributor.authorOztoprak, Nefise
dc.contributor.authorDuro, Raquel
dc.contributor.authorAlmajid, Fahad
dc.contributor.authorDogan, Mustafa
dc.contributor.authorDauby, Nicolas
dc.contributor.authorGunst, Jesper Damsgaard
dc.contributor.authorTekin, Recep
dc.contributor.authorKonopnicki, Deborah
dc.contributor.authorPetrosillo, Nicola
dc.contributor.authorBozkurt, Ilkay
dc.contributor.authorWadi, Jamal
dc.contributor.authorPopescu, Corneliu
dc.contributor.authorBalkan, Ilker Inanc
dc.contributor.authorOzer-Balin, Safak
dc.contributor.authorZupanc, Tatjana Lejko
dc.contributor.authorCascio, Antonio
dc.contributor.authorDumitru, Irina Magdalena
dc.contributor.authorErdem, Aysegul
dc.contributor.authorErsoz, Gulden
dc.contributor.authorTasbakan, Meltem
dc.contributor.authorAjamieh, Oday Abu
dc.contributor.authorSirmatel, Fatma
dc.contributor.authorFlorescu, Simin
dc.contributor.authorGulsun, Serda
dc.contributor.authorOzkaya, Hacer Deniz
dc.contributor.authorSari, Sema
dc.contributor.authorTosun, Selma
dc.contributor.authorAvci, Meltem
dc.contributor.authorCag, Yasemin
dc.contributor.authorCelebi, Guven
dc.contributor.authorSagmak-Tartar, Ayse
dc.contributor.authorKarakus, Sumeyra
dc.contributor.authorSener, Alper
dc.contributor.authorDedej, Arjeta
dc.contributor.authorOncu, Serkan
dc.contributor.authorDel Vecchio, Rosa Fontana
dc.contributor.authorOzturk-Engin, Derya
dc.contributor.authorAgalar, Canan
dc.date.accessioned2019-10-27T09:41:38Z
dc.date.available2019-10-27T09:41:38Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractInfective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).en_US
dc.identifier.doi10.1007/s10096-019-03607-xen_US
dc.identifier.endpage1763en_US
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.issue9en_US
dc.identifier.pmid31187307en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1753en_US
dc.identifier.urihttps://doi.org/10.1007/s10096-019-03607-x
dc.identifier.urihttps://hdl.handle.net/11454/28658
dc.identifier.volume38en_US
dc.identifier.wosWOS:000481757500021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInfective endocarditisen_US
dc.subjectProstheticen_US
dc.subjectNativeen_US
dc.subjectSen_US
dc.subjectaureusen_US
dc.subjectBlood cultureen_US
dc.titlePortraying infective endocarditis: results of multinational ID-IRI studyen_US
dc.typeArticleen_US

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