Relationship Between IL1 beta-511C > T and ILRN VNTR Polymorphisms and Keratoconus

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dc.contributor.authorPalamar, Melis
dc.contributor.authorOnay, Huseyin
dc.contributor.authorOzdemir, Taha Resid
dc.contributor.authorArslan, Esra
dc.contributor.authorEgrilmez, Sait
dc.contributor.authorÖzkınay, Ferda
dc.contributor.authorYagci, Ayse
dc.date.accessioned2019-10-27T22:05:23Z
dc.date.available2019-10-27T22:05:23Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose:The aim of this study was to evaluate the relationship between keratoconus (KC) and interleukin-1 (IL1 ) (-511C>T) and interleukin-1 receptor antagonist (IL1RN) variable number of tandem repeat (VNTR) polymorphisms that are potentially associated in their genetic susceptibility to KC.Methods:A total of 121 patients with KC and 121 healthy individuals were enrolled. Blood samples with ethylenediamine tetraacetic acid were obtained, and IL1 (-511C>T) (rs16944) (polymerase chain reaction-restriction fragment length polymorphism method) and IL1RN VNTR polymorphisms (rs2234663) (polymerase chain reaction and agarose gel imaging) were investigated.Results:Genotype and allele distribution for IL1 (-511C>T) and IL1RN VNTR polymorphisms among the KC and healthy groups showed no difference (for all; P > 0.05).Conclusions:Because the genotype and allele frequency of both polymorphisms are identical, it is most likely that IL1-511C>T and IL1RN VNTR polymorphisms do not play a role in the development of KC in the Turkish population.en_US
dc.identifier.doi10.1097/ICO.0000000000000027en_US
dc.identifier.endpage147en_US
dc.identifier.issn0277-3740
dc.identifier.issn1536-4798
dc.identifier.issue2en_US
dc.identifier.pmid24322806en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.1097/ICO.0000000000000027
dc.identifier.urihttps://hdl.handle.net/11454/48399
dc.identifier.volume33en_US
dc.identifier.wosWOS:000329903900008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCorneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjectgeneticsen_US
dc.subjectinterleukinen_US
dc.subjectkeratoconusen_US
dc.subjectpolymorphismen_US
dc.titleRelationship Between IL1 beta-511C > T and ILRN VNTR Polymorphisms and Keratoconusen_US
dc.typeArticleen_US

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