Ocular manifestations of granulomatosis with polyangiitis: report from a tertiary eye care center

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dc.authoridkorkmaz, ilayda/0000-0001-8043-8632
dc.authoridPalamar, Melis/0000-0002-2494-0131
dc.authoridKeser, Gokhan/0000-0001-7289-1816
dc.authoridEgrilmez, Sait/0000-0002-6971-527X
dc.contributor.authorKorkmaz, Ilayda
dc.contributor.authorSelver, Ozlem Barut
dc.contributor.authorEgrilmez, Sait
dc.contributor.authorYagci, Ayse
dc.contributor.authorKeser, Gokhan
dc.contributor.authorAksu, Kenan
dc.contributor.authorPalamar, Melis
dc.date.accessioned2024-08-31T07:48:19Z
dc.date.available2024-08-31T07:48:19Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractPurposeTo report demographic characteristics and ophthalmological manifestations of patients with granulomatosis with polyangiitis (GPA) in a tertiary eye care center in Turkey.MethodsMedical records of patients with GPA-related ocular manifestations evaluated between 2013 and 2023 were included. Demographic and clinical characteristics of the patients including nature of systemic involvement, ophthalmologic symptoms and signs, laboratory investigations and treatment modality were reviewed.ResultsTwelve eyes of 10 patients (5 female/5 male) were included. The mean age was 57.2 +/- 12.2 (35-71) years. Five (50%) patients were already diagnosed with GPA. Ocular involvement was the first manifestation of GPA in 3 patients. The remaining 2 patients had simultaneous systemic and ocular symptoms at presentation. Conjunctival hyperemia (9 eyes) and pain (7 eyes) were the most frequent presenting symptoms followed by blurred vision (3 eyes). The frequencies of ocular manifestations were as follows:episcleritis (3 eyes), isolated peripheral ulcerative keratitis (PUK) (3 eyes), scleritis (3 eyes), simultaneous PUK and scleritis (2 eyes) and periorbital mass (1 eye).ConclusionOphthalmological manifestations can be the initial findings in GPA. Since GPA can affect different structures of the eye, it sometimes might be challenging for ophthalmologists. Therefore, it is crucial for ophthalmologists to be well-informed about GPA-related ocular findings and to have a high index of suspicion for GPA. Although PUK associated with scleritis is highly suggestive for GPA, isolated cases of PUK or scleritis can be seen in GPA. Therefore, it is important to adopt a multidisciplinary approach, consider GPA in differential diagnosis, and benefit from accurate diagnostic tests.en_US
dc.identifier.doi10.1007/s10792-024-02989-y
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue1en_US
dc.identifier.pmid38321188en_US
dc.identifier.scopus2-s2.0-85184529322en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s10792-024-02989-y
dc.identifier.urihttps://hdl.handle.net/11454/104720
dc.identifier.volume44en_US
dc.identifier.wosWOS:001166171800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectEpiscleritisen_US
dc.subjectGranulomatosis With Polyangiitisen_US
dc.subjectPeripheral Ulcerative Keratitisen_US
dc.subjectScleritisen_US
dc.titleOcular manifestations of granulomatosis with polyangiitis: report from a tertiary eye care centeren_US
dc.typeArticleen_US

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