Aggregometry Response to Half-dose Prasugrel in Flow-diverting Stent Implantation
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Science and Business Media Deutschland GmbH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: The aim of this study was to determine whether half-dose loading (30?mg) of prasugrel is sufficient to achieve adequate platelet inhibition, and whether such a loading dose of prasugrel together with aspirin followed by a 10?mg/day prasugrel maintenance, could serve as a first-line antiplatelet strategy for patients undergoing flow-diverting stent (FDS) implantation. Methods: Data from a group of consecutive patients treated for intracranial aneurysm with FDS were retrospectively collected. Platelet P2Y12 receptor responsiveness was assessed by a rapid platelet function test just prior to the procedure. All ischemic and hemorrhagic complications as well as morbidity and mortality rates were documented. Results: A total of 138 patients with 153 aneurysms (32 were symptomatic and 121 were incidental) underwent FDS treatment in a total of 147 loading sessions. Adequate platelet inhibition was obtained in 136/138 (98.5%) patients and 145/147 (98.6%) loading sessions. Overall, there was one case of (hemorrhagic) mortality (0.7%), one of (ischemic) morbidity (0.7%), one of symptomatic (hemorrhagic) clinical complications without permanent deficits (0.7%), and six transient ischemic attacks (4.1%). The 6?month control angiography, available for all patients, revealed a 95.4% aneurysm occlusion rate. Conclusion: Half-dose (30?mg) prasugrel loading results in effective platelet P2Y12 receptor inhibition in more than 98% of patients. Dual antiaggregant loading with half dose prasugrel followed by prasugrel maintenance as a first-line therapy appears to be feasible in patients treated with FDS implantation for intracranial aneurysm. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
Açıklama
Anahtar Kelimeler
Aneurysm, Antiplatelet agents, Flow diversion, Loading dose, Platelet function test, acetylsalicylic acid, prasugrel, purinergic P2Y12 receptor, acetylsalicylic acid, antithrombocytic agent, prasugrel, adult, Article, brain angiography, brain ischemia, controlled study, female, human, impedance, impedance aggregometry, implantation, intracranial aneurysm, loading drug dose, maintenance therapy, major clinical study, male, middle aged, morbidity, mortality rate, retrospective study, subdural hematoma, thrombocyte function, transient ischemic attack, diagnostic imaging, intracranial aneurysm, stent, Aspirin, Cerebral Angiography, Female, Humans, Intracranial Aneurysm, Male, Middle Aged, Platelet Aggregation Inhibitors, Prasugrel Hydrochloride, Retrospective Studies, Stents
Kaynak
Clinical Neuroradiology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
30
Sayı
3
