Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals

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dc.contributor.authorEntezari, Bita
dc.contributor.authorBozdag, Deniz
dc.contributor.authorGurer-Orhan, Hande
dc.date.accessioned2023-01-12T20:30:07Z
dc.date.available2023-01-12T20:30:07Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractThe incidence of obesity and related diseases has increased dramatically in the last decade. Some endocrine disruptors have been shown to interact with metabolic processes via various cellular mechanisms, and disrupt homeostasis in adipose tissue, resulting in weight gain and obesity. These chemicals are called “obesogens”. Today, with the increased use of industrial chemicals, individuals are exposed to a mixture of chemicals at very low doses. Most of these industrial chemicals have been investigated for their possible endocrine-disrupting and obesogenic effects. Besides these chemicals, pharmaceuticals can also have similar adverse effects; however, limited studies have been performed to investigate such effects of drugs. Furthermore, there are few studies investigating the relationship between prenatal exposure to pharmaceuticals and childhood obesity. Therefore, to clarify the endocrine-disrupting and obesogenic effects of the pharmaceuticals, which are prescribed during pregnancy, mechanistic studies should be performed, and necessary precautions should be taken. In this paper, we reviewed the mechanisms of obesogens, briefly overview several well-known obesogenic industrial chemicals, and focused more on potential obesogenic pharmaceuticals.en_US
dc.identifier.doi10.26650/IstanbulJPharm.2022.1027027
dc.identifier.endpage226en_US
dc.identifier.issn2548-0731
dc.identifier.issn2587-2087
dc.identifier.issue2en_US
dc.identifier.startpage216en_US
dc.identifier.trdizinid1122534en_US
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2022.1027027
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1122534
dc.identifier.urihttps://hdl.handle.net/11454/80725
dc.identifier.volume52en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.relation.ispartofIstanbul Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleObesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticalsen_US
dc.typeArticleen_US

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