Feasibility of using thrombin generation assay (TGA) for monitoring of haemostasis during supplementation therapy in haemophilic patients without inhibitors

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dc.contributor.authorAy, Y.
dc.contributor.authorBalkan, C.
dc.contributor.authorKarapinar, D. Y.
dc.contributor.authorAkin, M.
dc.contributor.authorBilenoglu, B.
dc.contributor.authorKavakli, K.
dc.date.accessioned2019-10-27T21:40:55Z
dc.date.available2019-10-27T21:40:55Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractMonitoring factor replacement treatment and observing concordance with clinical haemostasis is crucial in vital haemorrhages and major surgeries in haemophilic patients. We aimed to investigate the value of the thrombin generation assay (TGA) and thromboelastography (TEG) for monitoring haemostasis in haemophilic patients during factor replacement treatment. The study group consisted of 29 patients (21 haemophilia A, 8 haemophilia B). All the patients FVIII-inhibitor were negative. A total of 35 bleeding episodes and/or surgical interventions were evaluated. aPTT, FVIII/FIX activity, TEG and TGA tests were conducted before and after factor therapy during the bleeding episode or surgical prophylaxis of haemophilic patients. Correlations among these tests were evaluated and compared with clinical responses. No correlation was found among aPTT, factor activities and clinical outcome. There were also no correlation found between TEG parameters and clinical outcome. The only significant correlation found between TGA parameters and clinical outcome was the correlation between peak thrombin. In conclusion, we found superiority of TGA-peak thrombin over other traditional tests for monitoring haemostasis in haemophilic patients in this study.en_US
dc.identifier.doi10.1111/j.1365-2516.2012.02849.xen_US
dc.identifier.endpage916en_US
dc.identifier.issn1351-8216
dc.identifier.issue6en_US
dc.identifier.pmid22639879en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage911en_US
dc.identifier.urihttps://doi.org/10.1111/j.1365-2516.2012.02849.x
dc.identifier.urihttps://hdl.handle.net/11454/46445
dc.identifier.volume18en_US
dc.identifier.wosWOS:000310553600027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofHaemophiliaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthaemophiliaen_US
dc.subjectthrombin generation assayen_US
dc.subjectthromboelastographyen_US
dc.titleFeasibility of using thrombin generation assay (TGA) for monitoring of haemostasis during supplementation therapy in haemophilic patients without inhibitorsen_US
dc.typeArticleen_US

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