The effects of steroidal and non-steroidal anti-inflammatory drugs on tracheal wound healing in an experimental rat model

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dc.contributor.authorDuman, Elif
dc.contributor.authorCeylan, Kenan Can
dc.contributor.authorAkpinar, Deniz
dc.contributor.authorYucel, Nur
dc.contributor.authorUnsal, Saban
dc.contributor.authorDuman, Soner
dc.contributor.authorKaya, Seyda Ors
dc.date.accessioned2020-12-01T12:01:41Z
dc.date.available2020-12-01T12:01:41Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVES: the effect of non-steroidal anti-inflammatory drugs (NSAID), mostly used for postoperative analgesic purposes for wound healing, is still a matter of debate. Our goal was to evaluate the effects of the most widely used NSAID and corticosteroids after surgical operations on tracheal wound healing in an experimental rat model. METHODS: Thirty-nine male Wistar albino rats were included in this study. Tracheotomy was performed in 32 rats; then they were divided into 3 groups. After the first day, the animals in group 1 were treated with an NSAID (diclofenac 10 mg/kg/day) (NSAID, n = 12) for 7 days; the animals in group 2 were treated with a corticosteroid (dexamethasone, 2 x 0.1 mg/kg/day) (steroid, n = 10) for 7 days; the animals in group 3 (control, n = 10) were not given any medications. For a fourth group (histological control, n = 7), in order to evaluate normal morphological and histological characteristics, neither surgery nor medication was used. Five rats were eliminated from the study (2 rats in the NSAID group died and 3 rats in the steroid group developed local wound infections). the drop-out rate was 12.8%. Histological characteristics, inflammation, fibrosis, necrosis, neochondrogenesis, neovascularization and epithelization were evaluated in 34 rats. Nonparametric tests were used for statistical analysis. RESULTS: Inflammation, vascularization and number of fibroblasts and chondrocytes were significantly higher in the control group than in the histological control group. There was some reduction in all parameters except vascularization in the NSAID group (P > 0.05). When the steroid group was compared to the NSAID group, inflammation (P < 0.05), vascularization and number of chondrocytes (P > 0.05) were more suppressed in the steroid group. the number of fibroblasts increased in the steroid group (P > 0.05). CONCLUSIONS: Steroids and NSAID may have negative effects on tracheal wound healing, probably by suppressing inflammation and fibroblast proliferation. NSAID was mostly used postoperatively for analgesic purposes and should be avoided.en_US
dc.identifier.doi10.1093/icvts/ivz309en_US
dc.identifier.endpage651en_US
dc.identifier.issn1569-9293
dc.identifier.issn1569-9285
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage646en_US
dc.identifier.urihttps://doi.org/10.1093/icvts/ivz309
dc.identifier.urihttps://hdl.handle.net/11454/62497
dc.identifier.volume30en_US
dc.identifier.wosWOS:000537403700025en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofInteractive Cardiovascular and Thoracic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectWound healingen_US
dc.subjectSteroidsen_US
dc.subjectNon-steroidal anti-inflammatory drugsen_US
dc.subjectInflammationen_US
dc.titleThe effects of steroidal and non-steroidal anti-inflammatory drugs on tracheal wound healing in an experimental rat modelen_US
dc.typeArticleen_US

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