Emulsion Formulations of Indomethacine and Xylometazoline Hydrochloride for Intranasal Delivery

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dc.contributor.authorGümüştaş, Barış
dc.contributor.authorCingi, Cemal
dc.contributor.authorİnce, İskender
dc.contributor.authorTürkyılmaz, Gülbeyaz Yıldız
dc.contributor.authorKarasulu, Yeşim
dc.date.accessioned2023-01-12T20:29:16Z
dc.date.available2023-01-12T20:29:16Z
dc.date.issued2020
dc.departmentN/A/Departmenten_US
dc.description.abstractNasal administration has many advantages over parenteral and oral administration. Some drugs are ineffective when administered orally due to absorption and first pass metabolism. Therefore, if the aqueous solubility problem can be overcome, the intranasal route will be an alternative method for administration. In this study, emulsion formulation was proposed as a new approach in order to increase the duration of the indomethacinxylometazoline hydrochloride combination in the nose. The pH value of F1 and F2 emulsions were determined 9.4 and as 5.6 respectively. The particle size of F1 and F2 formulations were found to be 136.8±24 nm and 269.5±66 nm respectively. Formulation of o/w emulsion IND and XYL may be considered as an alternative to iv and po administration. This administration of drugs may be delivery to achieve rapid onset of its pharmacological effect.en_US
dc.identifier.doi10.18185/erzifbed.836484
dc.identifier.endpage961en_US
dc.identifier.issn2149-4584
dc.identifier.issue3en_US
dc.identifier.startpage956en_US
dc.identifier.trdizinid475418en_US
dc.identifier.urihttps://doi.org/10.18185/erzifbed.836484
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/475418
dc.identifier.urihttps://hdl.handle.net/11454/80413
dc.identifier.volume13en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofErzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEmulsion Formulations of Indomethacine and Xylometazoline Hydrochloride for Intranasal Deliveryen_US
dc.typeArticleen_US

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