Treatment of delta hepatitis

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dc.contributor.authorGunsar, Fulya
dc.date.accessioned2019-10-27T21:52:14Z
dc.date.available2019-10-27T21:52:14Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractHepatitis delta virus (HDV) is a defective RNA virus that depends on hepatitis B virus (HBV) for its lifecycle. Treatment of chronic HDV infection is difficult as it does not have an enzymatic function as a target, such as polymerases and proteases of HBV and hepatitis C virus. Recently, it has been suggested that farnesyl transferase could be an enzymatic target. Currently, interferon is the only agent against HDV infection. Virological response has risen to 20-47% with pegylated interferon. Monotherapy of nucleos(t)ide analogs are ineffective against the HDV infection, but adefovir and pegylated interferon combination therapy have had some advantages for reduction of HBV surface antigen (HBsAg) levels. Recent studies suggest that measuring HBsAg levels during treatment could be more meaningful than HDV RNA negativity to predict virological response. Prenylation inhibitors that can affect the interactions between the large HDV antigen and HBsAg in the HDV virion are expected treatments for HDV infection. More studies are needed to understand the molecular mechanisms of HDV to manage the disease.en_US
dc.identifier.doi10.1586/ERI.13.35en_US
dc.identifier.endpage498en_US
dc.identifier.issn1478-7210
dc.identifier.issn1744-8336
dc.identifier.issue5en_US
dc.identifier.pmid23627855en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage489en_US
dc.identifier.urihttps://doi.org/10.1586/ERI.13.35
dc.identifier.urihttps://hdl.handle.net/11454/47553
dc.identifier.volume11en_US
dc.identifier.wosWOS:000320165000011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofExpert Review of Anti-Infective Therapyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchronic delta hepatitisen_US
dc.subjecthepatitis D virusen_US
dc.subjectinterferonen_US
dc.subjectpegylated interferonen_US
dc.subjectprenylation inhibitorsen_US
dc.subjecttreatmenten_US
dc.titleTreatment of delta hepatitisen_US
dc.typeReview Articleen_US

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