Value of gingival crevicular fluid TREM-1, PGLYRP1, and IL-1 & beta; levels during menopause

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dc.authorscopusid57204391655
dc.authorscopusid35609889700
dc.authorscopusid57267616700
dc.authorscopusid35734773300
dc.authorscopusid6701658370
dc.authorscopusid14059543900
dc.authorscopusid57208499273
dc.contributor.authorYakar, Nil
dc.contributor.authorEmingil, Gulnur
dc.contributor.authorTüredi, Asena
dc.contributor.authorSahi, Çağdaş
dc.contributor.authorKöse, Timur
dc.contributor.authorBostancı, Nagihan
dc.contributor.authorSilbereisen, Angelika
dc.date.accessioned2024-08-25T18:31:51Z
dc.date.available2024-08-25T18:31:51Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectiveThis study aimed to investigate the association of GCF TREM-1, PGLYRP1, and IL-1 & beta; levels with periodontal health in pre- and postmenopausal women. BackgroundTriggering receptor expressed on myeloid cells 1 (TREM-1), activated through its ligand peptidoglycan recognition protein 1 (PGLYRP1), stimulates proinflammatory cytokine production, such as interleukin (IL)-1 & beta;, during periodontal inflammation. Postmenopausal changes may modulate these immune-inflammatory functions. No clinical study has yet investigated the effect of menopause on TREM-1, PGLYRP1, and IL-1 & beta; levels in gingival crevicular fluid (GCF). MethodsThis cross-sectional study included 148 women (age range = 35-65 years), divided into postmenopausal women (PMW) (n = 76, mean age = 54 & PLUSMN; 5 years) and regularly menstruating premenopausal women (RMPW) (n = 72, mean age = 40 & PLUSMN; 4 years). Clinical periodontal parameters were recorded. TREM-1, PGLYRP1, and IL-1 & beta; levels were quantified with enzyme-linked immunosorbent assays. Pearson's Chi-squared test and Mann-Whitney-U test were used to compare categorical and numerical variables, respectively. Spearman's Rho correlation analysis was used to test the linear relationship between variables. Analyte level data were categorized based on the periodontal diagnosis and menopause status (2 x 2 nonparametric factorial ANOVA). ResultsNo significant differences in TREM-1, PGLYRP1, and IL-1 & beta; levels between PMW and RMPW were observed (p > .05). Mean values of periodontal indexes including probing depth did not differ significantly between PMW and RMPW groups (p = .474). TREM-1 levels were significantly higher in both PMW and RMPW with periodontitis, compared to gingivitis or health (p = .0021). ConclusionMenopause-related changes have no observable effect on GCF levels of TREM-1, PGLYRP1, and IL-1 & beta;. Higher GCF TREM-1 levels in women with periodontitis regardless of their menopausal status indicate that TREM-1 may be an indicator for periodontitis both in premenopausal and postmenopausal women.en_US
dc.identifier.doi10.1111/jre.13167
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.pmid37529985en_US
dc.identifier.scopus2-s2.0-85166617936en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/jre.13167
dc.identifier.urihttps://hdl.handle.net/11454/100046
dc.identifier.wosWOS:001041031300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectcytokinesen_US
dc.subjectgingival crevicular fluiden_US
dc.subjectperiodontal diagnosisen_US
dc.subjectMyeloid Cells-1 Strem-1en_US
dc.subjectMetalloproteinasesen_US
dc.subjectInflammationen_US
dc.subjectIl-1-Betaen_US
dc.subjectMediatorsen_US
dc.subjectDiseasesen_US
dc.subjectDensityen_US
dc.titleValue of gingival crevicular fluid TREM-1, PGLYRP1, and IL-1 & beta; levels during menopauseen_US
dc.typeArticleen_US

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