A rare long-term side effect of COVID-19 vaccines: Symmetrical drug-related intertriginous and flexural exanthema-like reaction SDRIFE and potential immunogens for delayed type hypersensitivity reactions

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dc.authorid0009-0006-5836-8459
dc.authorid0000-0001-6295-211X
dc.authorid0000-0002-3849-9367
dc.authorid0000-0002-2794-1746
dc.authorid0000-0003-1121-9967
dc.authorid0000-0002-3099-9172
dc.contributor.authorDemir, Meryem
dc.contributor.authorDuman, Nilay
dc.contributor.authorAkten, Hatice Serpil
dc.contributor.authorInan, Sinem
dc.contributor.authorOkan, Kasim
dc.contributor.authorYildirim, Onurcan
dc.contributor.authorGoksel, Ozlem
dc.contributor.authorKarakus, Haydar Soydaner
dc.contributor.authorOzgur, Su
dc.date.accessioned2025-02-24T07:22:13Z
dc.date.available2025-02-24T07:22:13Z
dc.date.issued2024
dc.departmentEge Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları ABD
dc.description.abstractBackground: Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is an important clinical entity that is rare and may develop with a Type IV delayed type hypersensitivity immune response to drug antigens. The incidence and characteristics of SDRIFE attributed to COronaVIrus Disease of 2019 (COVID-19) vaccines remain unclear, this issue requires further elucidation. Objective: We aim to investigate the vaccine-related-SDRIFE and potential immunogens of COVID-19 vaccines through a literature review accompanied by a real case. Methods: A new vaccine related-SDRIFE case report and a literature review regarding COVID Vaccine related SDRIFE. In the years following the COVID vaccinations, all SDRIFE cases published between 2000 and 2024 were retrieved. Results: The new case of vaccine-related SDRIFE developed following the COVID-19 Pfizer-BioNTech vaccine and was tolerated without any issues with the CoronaVac vaccine (Sinovac Biotech.,China) after negative skin tests. A literature search has revealed fifteen different types of SDRIFE cases related to COVID-19 vaccines since 2020. Diagnostic skin testing with vaccine or any potentially immunogen parts of vaccine were performed in six patients. All tests were negative except for one late intradermal test positivity. Conclusion: This mini review showed that SDRIFE due to COVID vaccines is a rare, but a significant adverse event that has a potential to impair patient compliance with subsequent vaccines. Identification and avoidance of potential allergens through standardized skin tests and diagnostic immunological work-up will contribute to vaccine compliance and better management of hypersensitivity reactions.
dc.identifier.citationDemir, M., Duman, N., Akten, H. S., Inan, S., Okan, K., Yildirim, O., Karakus, H. S., Ozgur, S., & Goksel, O. (2025). A rare long-term side effect of COVID-19 vaccines: Symmetrical drug-related intertriginous and flexural exanthema-like reaction SDRIFE and potential immunogens for delayed type hypersensitivity reactions. International Immunopharmacology, 145, 113737.
dc.identifier.doi10.1016/j.intimp.2024.113737
dc.identifier.endpage6
dc.identifier.issn1567-5769
dc.identifier.issueDec
dc.identifier.pmid39642561
dc.identifier.scopus2-s2.0-85211044914
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2024.113737
dc.identifier.urihttps://hdl.handle.net/11454/116169
dc.identifier.volume145
dc.identifier.wosWOS:001375478600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDemir, Meryem
dc.institutionauthorDuman, Nilay
dc.institutionauthorAkten, Hatice Serpil
dc.institutionauthorInan, Sinem
dc.institutionauthorOkan, Kasim
dc.institutionauthorYildirim, Kasim
dc.institutionauthorYildirim, Onurcan
dc.institutionauthorGoksel, Ozlem
dc.institutionauthorKarakus, Haydar Soydaner
dc.institutionauthorOzgur, Su
dc.institutionauthorid0009-0006-5836-8459
dc.institutionauthorid0000-0001-6295-211X
dc.institutionauthorid0000-0002-3849-9367
dc.institutionauthorid0000-0002-2794-1746
dc.institutionauthorid0000-0003-1121-9967
dc.institutionauthorid0000-0002-3099-9172
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Immunopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdvers reaction
dc.subjectCoronavirus vaccine
dc.subjectCOVID-19
dc.subjectMaculopapular eruptions
dc.subjectSDRIFE
dc.titleA rare long-term side effect of COVID-19 vaccines: Symmetrical drug-related intertriginous and flexural exanthema-like reaction SDRIFE and potential immunogens for delayed type hypersensitivity reactions
dc.typeArticle

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